摘要
运动功能是在神经系统的调控下完成的,皮层及基底神经节在运动功能调节中发挥信息整合及指令发放的作用,其中纹状体是基底神经节中接受传入信息的主要核团。腺苷A2A受体(adenosine A2A receptor, A2AR)在纹状体中高度表达,并在纹状体中整合多巴胺、谷氨酸和大麻素信号,参与间接通路运动抑制的信息编码。该文阐述了腺苷A2AR与多巴胺D2受体、代谢型谷氨酸mGlu5受体以及大麻素CB1受体的交互作用,探讨腺苷表达异常在神经疾病,如帕金森病、酒精成瘾等产生的作用,以及靶向干预腺苷改善相关疾病运动功能的机制,并对A2AR在间接通路运动调控及相关运动障碍中的研究进行总结,为后期运动功能中枢靶向干预提供理论参考。
Motor function is regulated by the nervous system. The cortex and basal ganglia play the role of motor information integrating processing and instruction delivery in motor control. Striatum is the main nucleus which receives the incoming information in the basal ganglia. Adenosine A2 A receptor(A2 AR) are highly expressed in the striatum, and it can integrate dopamine, glutamate and cannabinoid signals to participate in information coding in the indirect pathway of motor inhibition function. This paper reviewed the interaction among adenosine A2 AR, dopamine D2 receptor(D2 R), metabolic glutamate mGlu5 receptor(mGluR5) and cannabinoid CB1 receptor, and discussed the abnormal expression adenosine A2 AR in neurologic diseases, such as Parkinson’s disease and alcohol addiction. In addition, the review summarized the research on the A2 AR in the indirect pathway and motor dysfunction for providing theoretical reference for targeted intervention of motor regulation.
作者
韦叶兰
陈巍
黄浩洁
赵旭东
陈孟娇
张吉敏
侯莉娟
WEI Ye-Lan;CHEN Wei;HUANG Hao-Jie;ZHAO Xu-Dong;CHEN Meng-Jiao;ZHANG Ji-Min;HOU Li-Juan(School of Physical Education and Sports,Beijing Normal University,Beijing 100875,China;College of Physical Education,Hebei Normal University,Shijiazhuang 050021,China)
出处
《生命科学》
CSCD
北大核心
2020年第2期110-116,共7页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31971095)
国家级本科生科研训练与创新创业基金(311310002)。
