摘要
肠道菌群的稳定在维持机体健康中发挥重要作用,当便秘引起肠道菌群失衡时,它通过干扰胆汁酸(bile acids,BAs)的合成影响脂质消化、吸收过程;肠道菌群代谢物短链脂肪酸(short chain fatty acids,SCFAs)减少可破坏肠道黏膜屏障的完整性,且SCFAs的受体不能被激活,此外,氧化三甲胺(trimethylamine oxide,TMAO)产生量增多影响脂质代谢过程中关键酶的表达,进一步影响脂质转运、清除过程.本文就便秘状态下肠道菌群通过BAs、SCFAs、TMAO的变化介导脂代谢紊乱的机制作一综述.
The stability of gut microbiota plays an important role in maintaining the health of the body.The gut microbiota is imbalanced when constipation occurs,thus affecting the process of lipid digestion and absorption by interfering with the synthesis of bile acids(BAs).The decrease of short chain fatty acids(SCFAs),a metabolite of gut microbiota,can destroy the integrity of the intestinal mucosal barrier,and their receptors cannot be activated.In addition,the increase of trimethylamine oxide(TMAO)alters the expression of key enzymes in lipid metabolism,and further affects the lipid transport and clearance.This article reviews the mechanism for changes of gut microbiota in constipation to mediate lipid metabolism disorders with regard to changes in BAs,SCFAs,and TMAO.
作者
徐玉洁
张亚峰
许翠萍
Yu-Jie Xu;Ya-Feng Zhang;Cui-Ping Xu(First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,Shanxi Province,China;Department of Gastroenterology,The First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China)
出处
《世界华人消化杂志》
CAS
2020年第9期341-346,共6页
World Chinese Journal of Digestology
关键词
便秘
肠道菌群
脂代谢
胆汁酸
短链脂肪酸
氧化三甲胺
Constipation
Gut microbiota
Bile acids
Short chain fatty acids
Trimethylamine oxide
