摘要
目的研究分析血栓弹力图联合凝血指标对急性脑梗死患者早期神经功能障碍的预测价值。方法选取184例神经内科确诊为急性脑梗死的患者作为研究对象,根据患者入院3 d内是否出现早期神经功能障碍进行分组,其中出现早期神经功能恶化的90例患者作为障碍组,未出现早期神经功能恶化的94例患者为无障碍组,采用Logistic回归分析血栓弹力图联合凝血指标与早期神经功能障碍的关系。结果障碍组男性患者明显低于非障碍组,障碍组既往史存在糖尿病患者数明显多于非障碍组,障碍组存在抽烟习惯的患者数明显低于非障碍组,二者比较差异有统计学意义(P<0.05);障碍组患者C反应蛋白水平明显高于非障碍组,差异有统计学意义(P<0.05)。无障碍组患者血栓弹力图反应时间及动力时间明显高于障碍组,差异有统计学意义(P<0.05);2组患者血栓弹力图的角度及最大血块强度比较差异无统计学意义(P>0.05);障碍组患者凝血酶原时间(PT)及活化部分凝血活酶时间(APTT)明显低于无障碍组(P<0.05);无障碍组患者纤维蛋白原(FIB)水平明显低于障碍组(P<0.05)。Lojistic多因素回归分析结果表明,早期神经功能障碍与血栓弹力图以及凝血指标有相关性。结论血栓弹力图联合凝血时间缩短对急性脑梗死患者早期神经功能障碍具有一定预测价值。
Objective To study the predictive value of thromboelastography combined with coagulation parameters for early neurological dysfunction in patients with acute cerebral infarction.Methods 184 patients with acute cerebral infarction confirmed by our neurology department were divided into the dysfunction group(n=90,early neurological dysfunction)and the non-dysfunction group(n=94,no early neurological dysfunction)according to the presence of early neurological dysfunction within 3 days after admission.Logistic regression was used to analyze the relationship between thromboelastography combined with coagulation parameters and early neurological dysfunction.Results The male patients in the dysfunction group were significantly lower than the non-dysfunction group,the number of patients with diabetes in dysfunction group was significantly higher than that in non-dysfunction group.The number of patients with smoking habits in the dysfunction group was significantly lower than that in the non-dysfunction group(P<0.05).The level of C-reactive protein in the dysfunction group was significantly higher than that in the non-dysfunction group(P<0.05).The response time and motivation time of the thromboelastography in the non-dysfunction group were significantly higher than those in the dysfunction group(P<0.05).There was no statistically significant difference between the two groups in terms of the angle of thromboelastography and the maximum clot strength(P>0.05).PT and APTT were significantly lower in the dysfunction group than in the non-dysfunction group(P<0.05).The FIB level in the non-dysfunction group was significantly lower than that in the dysfunction group(P<0.05).Logistic multivariate regression analysis showed that early neurological dysfunction was associated with thromboelastography and coagulation parameters.Conclusion The combination of thromboelastography and clotting time has a certain predictive value for early neurological dysfunction in patients with acute cerebral infarction.
作者
陈月婵
张红升
巳芳芳
CHEN Yuechan;ZHANG Hongsheng;SI Fangfang(Department of Laboratory,The Affiliated Hospital of Henan Medical College,Zhengzhou 451191,China;Department of Blood Transfusion,The First People's Hospital of Zhengzhou,Zhengzhou 451000,Chian)
出处
《宁夏医学杂志》
CAS
2020年第4期347-349,共3页
Ningxia Medical Journal
关键词
血栓弹力图
凝血指标
联合
急性脑梗死
早期神经功能障碍
预测
Thromboelastography
Coagulation parameters
Combination
Acute cerebral infarction
Early neurological dysfunction
Prediction
