摘要
目的研究不同精子质量组男性精液铝、铅、镉、铬、锰浓度与精子质量的关系。方法收集2019年1月至2019年6月前来生殖中心就诊的男性精液样本170例,通过计算机辅助精子分析仪(CASA)行精液常规分析,根据精子质量状况分为对照组、少精子症组、弱精子症组和少弱精子症组,并采用电感耦合等离子体质谱法(ICP-MS)对各组精液中铝、铅、镉、铬、锰浓度进行分析。结果与对照组相比,弱精子症组和少弱精子症组受试对象精液镉浓度较高,而铬浓度较对照组低,差异有统计学意义(P<0.05);弱精子症组和少弱精子症组受试对象精液铬浓度与少精子症组相比,差异有统计学意义(P<0.05);少精子症组、弱精子症组和少弱精子症组受试对象精液中铝、铅、锰浓度与对照组相比差异均无统计学意义(P>0.05)。进一步统计分析显示,中、重度弱精子症组精液镉浓度较对照组高,铬浓度较对照组低,差异均有统计学意义(P<0.05)。结论精液中高镉与低铬可能与非职业暴露于金属污染环境的男性精子质量差有关,可能导致弱精和少弱精子症状发生。
Objective To explore the relationship between the contents of aluminium,lead,cadmium,chromium and manganese in male semen and sperm quality in different sperm quality groups.Methods Semen samples of 170 men who came to visit reproductive center from January to June 2019 were collected,and routine sperm analysis was performed by computer-assisted sperm analyzer(CASA).According to the quality of sperm,they were divided into 4 groups:control group,oligospermia group,asthenospermia group and oligoasthenospermia group.And the contents of aluminum,lead,cadmium,chromium and manganese in semen of each group were analyzed by inductively coupled plasma mass spectrometry(ICP-MS).Results The concentration of cadmium in the asthenospermia group and the oligoasthenospermia group were higher than those in the control group,while the chromium concentration in the asthenospermia group and the oligoasthenospermia group were lower than those in the control group,and the differences were statistically significant(P<0.05).Compared with the oligospermia group,the differences of the chromium concentrations of the asthenospermia group and the oligoasthenospermia group were statistically significant(P<0.05).The differences of the concentrations of semen aluminum,lead and manganese in the oligospermia group,the asthenospermia group and the oligoasthenospermia group were not statistically significant while comparing with those in the control group(P>0.05).Further analysis showed that the concentrations of cadmium in moderate and severe asthenospermia groups were statistically higher than those in the control group,while the concentrations of chromium were statistically lower than those in the control group,differences were statistically significant(P<0.05).Conclusion High cadmium and low chromium in semen may be related to the poor sperm quality of men without occupational exposure to metal-contaminated environments,which may lead to asthenospermia and oligoasthenospermia in men.
作者
庞艳芳
元辉雄
梁治鹏
陈偲
陈兴鸿
刘中林
于佩
韩梦然
陈文成
PANG Yanfang;YUAN Huixiong;LIANG Zhipeng;CHEN Si;CHEN Xinghong;LIU Zhonglin;YU Pei;HAN Mengran;CHEN Wencheng(Medical Laboratory Department of Affiliated Hospital,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Graduate School,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;School of Medical Laboratory,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China)
出处
《右江医学》
2020年第4期290-295,共6页
Chinese Youjiang Medical Journal
基金
广西高校科学技术研究项目(ZD2014099)
广西医疗卫生适宜技术开发与推广应用项目(S2018106)
百色市科学研究与技术开发计划项目(百科20182515)。
关键词
精子质量
重金属
轻金属
男性不育
sperm quality
heavy metal
light metal
male infertility
