摘要
综述了蒙药阿拉嘎-斑布有效提取物斑蝥素及斑蝥素衍生物在抗消化道肿瘤过程中的药理作用及生物学功能的改变,进而分析斑蝥素及斑蝥素衍生物在抗消化肿瘤方面的可能作用机制,并对近几年有关斑蝥素及斑蝥素衍生物在消化道肿瘤方面的研究成果及近况做一概述。以期为斑蝥素及斑蝥素衍生物在抗消化道肿瘤方面提供一定的参考。经查阅资料发现蒙药阿拉嘎-斑布有效提取物斑蝥素及斑蝥素衍生物对消化道肿瘤发生发展过程的抑制,可能是通过改变肿瘤细胞生物学行为发挥抗肿瘤作用。如改变肿瘤细胞周期、诱导肿瘤细胞凋亡、抑制肿瘤细胞增殖、侵袭和迁移能力等。
The pharmacological effects and biological function changes of cantharidin and cantharidin derivatives of Mongolian drug Alaga-canthus were reviewed. The possible mechanism of cantharidin and cantharidin derivatives on gastrointestinal tumors were analyzed. And the recent research results of cantharidin and cantharidin derivatives in gastrointestinal tumors were also summarized. We hope to provide some reference in the effects of cantharidin and cantharidin derivatives in gastrointestinal tumors. Through reviewing the data, we found the inhibition of the cantharidin and cantharidin derivatives of Mongolian drug Alaga-Banbu on the development of gastrointestinal tumors. The anti-tumor effect may work through changing the biological behavior of tumor cells, including changing tumor cell cycle, tumor cell apoptosis, inhibiting tumor cell proliferation, invasion and migration ability.
作者
吴亚男
邓秀玲
王海生
WU Yanan;DENG xiuling;WANG haisheng(School of Basic Medicine,Inner Mongolia Medical University,Hohhot Inner Mongolia 010110,China;Department of Molecular Biology and Biochemistry,Inner Mongolia Medical University,Hohhot Inner Mongolia 010110,China)
出处
《中国继续医学教育》
2020年第12期157-159,共3页
China Continuing Medical Education
关键词
消化道肿瘤
阿拉嘎-斑布
斑蝥素
去甲斑蝥素
斑蝥酸钠
斑蝥酸镁
肿瘤抑制
gastrointestinal tumor
alaga-banbu
cantharidin
norcantharidine
sodium cantharidin
cantharidin acid magnesium
tumor inhibition
