摘要
目的分析三阴性乳腺癌患者的病理特征和临床预后状况。方法方便抽取该医院收治的110例三阴性乳腺癌患者纳入试验组,选择于2008年1月—2012年2月,且抽取同期110例非三阴性乳腺癌患者纳入对照组,统计两组患者的病理分类结果、病理特征、生存率。结果试验组非特殊型浸润性癌例数(92例)明显多于对照组统计值(77例),差异有统计学意义(χ^2=5.743,P<0.05),试验组伴髓样特征的癌例数(10例)明显多于对照组统计值(2例),差异有统计学意义(χ^2=5.641,P<0.05),试验组浸润性小叶癌例数(1例)明显少于对照组统计值(7例),差异有统计学意义(χ^2=4.669,P<0.05),试验组混合性非特殊型浸润性癌-小叶癌例数(0例)显著少于对照组统计值(11例),差异有统计学意义(χ^2=11.578,P<0.01),试验组伴大汗腺分化的癌例数、其他类型例数(5例、2例)对比对照组统计值(8例、5例),差异有统计学意义(χ^2=0.735、1.328,P>0.05);试验组组织学分级为Ⅲ级例数、肿瘤直径大于2 cm例数、侵犯皮肤的例数、出现淋巴结转移例数(32例、65例、23例、59例)显著多于对照组统计值(7例、36例、1例、29例),差异有统计学意义(χ^2=19.478、15.394、22.636、17.045,P<0.01);试验组生存率(72.73%)显著低于对照组统计值(89.09%),差异有统计学意义(χ^2=9.534,P<0.01)。结论三阴性乳腺癌患者病理分类以非特殊型浸润性癌例数为主,其次是伴髓样特征的癌,和非三阴性乳腺癌患者对比,三阴性乳腺癌患者组织学分级为Ⅲ级、肿瘤直径大于2 cm、侵犯皮肤、出现淋巴结转移的情况更多,生存率更低。
Objective To analyze the pathological characteristics and clinical prognosis of patients with triple-negative breast cancer.Methods Convenient selection of 110 patients with triple-negative breast cancer admitted to our hospital were enrolled in the experimental group.From January 2008 to February 2012,110 patients with non-triple negative breast cancer were enrolled in the control group.Pathological classification results,pathological features,survival rate were compared.Results The number of non-specific invasive carcinomas in the experimental group(92 cases)was significantly higher than that of the control group(77 cases),and the data showed statistical significance(χ^2=5.743,P<0.05).The experimental group was associated with myeloid characteristics.The number of cancer cases(10 cases)was significantly higher than that of the control group(2 cases),and the data showed statistical significance(χ^2=5.641,P<0.05).The number of invasive lobular carcinomas in the experimental group(1 case)was significantly less.The statistical value of the control group(7 cases)showed statistical significance(χ^2=4.669,P<0.05).The number of mixed non-specific invasive carcinoma-lobular carcinomas in the experimental group(0 cases)was significantly less than that of the control group(11 cases),statistical significance of data indicators(χ^2=11.578,P<0.01),the number of cancer cases with apocrine differentiation in the experimental group,the number of other types of cases(5 cases,2 cases)compared with the control group statistics(8 cases,5 cases),the data index was not statistically significant(χ^2=0.735,1.328,P>0.05);the histological grade of the experimental group was grade III,the tumor diameter was more than 2 cm,and the skin was invaded.The number of cases with lymph node metastasis(32 cases,65 cases,23 cases,59 cases)was significantly more than the control group(7 cases,36 cases,1 case,29 cases)showed statistical significance(χ^2=19.478,15.394,22.636,17.045,P<0.01);the survival rate of the experimental group(72.73%)was significantly lower than that of the control group.The statistical value of the group(89.09%)showed statistical significance(χ^2=9.534,P<0.01).Conclusion The pathological classification of patients with triple-negative breast cancer is mainly based on the number of non-specific invasive carcinomas,followed by cancer with myeloid characteristics.Compared with non-triple-negative breast cancer patients,the histological grade of triple-negative breast cancer patients is grade III.The tumor is larger than 2 cm in diameter,invading the skin,showing more lymph node metastasis,and the survival rate is lower.
作者
黎辉
韩明其
陈明光
LI Hui;HAN Ming-qi;CHEN Ming-guang(Department of Pathology,the First Hospital of Nanping City,Nanping,Fujian Province,353000 China)
出处
《中外医疗》
2020年第2期29-31,共3页
China & Foreign Medical Treatment
关键词
三阴性乳腺癌
病理特征
临床预后
Triple negative breast cancer
Pathological features
Clinical prognosis
