摘要
患者,女,17岁。口腔糜烂及全身多发水疱1年余。组织病理示表皮下水疱,DIF示基底膜线状IgG沉积,盐裂IIF示循环抗体IgG真皮侧阳性,血清学检查VII胶原抗体阳性。确诊为获得性大疱性表皮松解症。给予泼尼松20 mg/d,氨苯砜100 mg/d治疗一周,水疱明显消退。目前仍在随访中。
A 17-year-old female presented with oral erosions and multiple vesicles all over her body for more than one year. Biopsy showed blisters in subepidermal. DIF showed linear deposition of IgG in the epidermal basement membrane. IIF on salt split skin showed IgG bind on the dermal side. Serologic testing showed positive for Collagen type VII antibody. The diagnosis of epidermolysis bullosa acquisita was made. Prednisone 20 mg/d and dapsone 100 mg/d were treated, and the vesicles were obviously subsided. The patient is under follow-up.
作者
张博文
周桂芝
周盛基
颜潇潇
孙勇虎
张福仁
ZHANG Bowen;ZHOU Guizhi;ZHOU Shengji;YAN Xiaoxiao;SUN Yonghu;ZHANG Furen(Shandong Provincial Hospital for Skin Diseases,Shandong University,Jinan 250022,China;Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250022,China)
出处
《中国麻风皮肤病杂志》
2020年第4期230-231,共2页
China Journal of Leprosy and Skin Diseases
