摘要
Graves'病是一种常见的器官特异性自身免疫性疾病,与其他自身免疫性疾病引起器官损伤不同,它表现为器官的高功能状态,临床特征为甲状腺功能亢进。在Graves’病中,甲状腺刺激性自身抗体模仿TSH的作用,刺激甲状腺细胞产生及分泌过多的甲状腺激素。目标抗原TSHR的分子结构是导致甲状腺刺激性自身抗体产生的主要原因。编码TSHR的基因位于人14号染色体长臂3区1带,翻译后完整的TSHR要经过一系列加工修饰,如糖基化,硫酸盐化,蛋白棕榈化及裂解和脱落等。近十年来我们对TSHR受体分子的结构和功能特点及其与Graves’病发病相关性等方面的研究有了更大突破。本文就此领域做一综述。
Graves'disease is a common organ-specific autoimmune disease.Different from organ damage caused by other autoimmune diseases,it is characterized by a high functional state of the organ and its clinical features are hyperthyroidism.In Graves'disease,thyroid-stimulating autoantibodies mimic the effect of TSH,stimulating thyroid cells to produce and secrete excess thyroid hormone.The molecular structure of the target antigen TSHR is the main cause of thyroid stimulating autoantibodies.The gene encoding TSHR is located in the long arm 3 region 1 region of human chromosome 14,and the complete TSHR after translation is subjected to a series of processing modifications such as glycosylation,sulfation,protein palmization,cleavage and shedding.In the past ten years,we have made greater breakthroughs in the study of the structural and functional characteristics of TSHR receptor molecules and their correlation with the pathogenesis of Graves'disease.This article provides an overview of this area.
作者
章晓芳
朱麒钱
ZHANG Xiaofang;ZHU Qiqian(Department of Endocrinology and Metabolism,Shaoxing People′s Hospital in Zhejiang Province,Shaoxing 312000,China)
出处
《中国现代医生》
2020年第5期183-187,共5页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2015KYB400)。
