摘要
研究生大黄、醋大黄和大黄炭的大承气汤对其泻下作用的差异性,将96只试验小鼠随机分为阳性对照组及空白对照组、生DCQ 6、10 g/kg剂量组、醋DCQ 6、10 g/kg剂量组和炭DCQ 6、10 g/kg剂量组,按20 mL/kg的剂量给药后,分别用代谢笼积分法、炭末推进作用及Na^+-K^+-ATPasc活性试验,比较生大黄、醋大黄和大黄炭的大承气汤对小鼠的正常泻下作用、炭末推进率及Na^+-K^+-ATPasc活性的差异。结果表明,生大黄、醋大黄和大黄炭对大承气汤的泻下作用的影响有差异,但其变化差异在一定程度上与生大黄、醋大黄和大黄炭存在着联系。生DCQ组、醋DCQ组和炭DCQ组与空白对照组及阳性对照组比较,其对正常小鼠正常泻下作用、炭末推进作用、抑制Na^+-K^+-ATPase活性的作用有差异,且给药组间比较,生DCQ组泻下作用的影响差异最显著。
To study the difference of the purging effect of rhubarb,vinegar rhubarb and rhubarb charcoal on Dachengqi decoction,96 experimental mice were randomly divided into positive control group,blank control group,DCQ 6,10 g/kg dose group,vinegar DCQ 6,10 g/kg dose group and carbon DCQ 6,10 g/kg dose group.The activities of rhubarb,rhubarb and Dachengqi decoction of rhubarb and rhubarb on normal diarrhea,propelling rate of carbon and Na^+-K^+-ATPasc activity in mice were compared.Results showed that the effects of rhubarb,rhubarb and rhubarb charcoal on the diarrhea of Dachengqi decoction were different,but the variation of Dachengqi decoction was related to rhubarb,rhubarb and rhubarb carbon.Compared with the blank control group and the positive control group,the DCQ group,the vinegar DCQ group and the carbon DCQ group had different effects on normal diarrhea,the propulsive effect of carbon end and the inhibition of the activity of Na^+-K^+-ATPase in normal mice,and the difference of the effect between the DCQ group and the DCQ group was the most significant.The effects of rhubarb,rhubarb and rhubarb carbon on the diarrhea of Dachengqi may be different,which may be related to the changes in the content of the main chemical composition of the radix dahuris,rhubarb and rhubarb charcoal.
作者
邱美雁
魏江存
张如
谢臻
江先再
韩倩
赵凤仙
QIU Mei-yan;WEI Jiang-cun;ZHANG Ru;XIE Zhen;JIANG Xian-zai;HAN Qian;ZHAO Feng-xian(Guangxi International Zhuang Medical Hospital,Nanning 530201,China;Guangxi University of Chinese Traditional Medicine,Nanning 530200,China;Guangxi Women and Children's Health Hospital,Nanning 530003,China)
出处
《湖北农业科学》
2020年第2期128-132,共5页
Hubei Agricultural Sciences
基金
国家自然科学基金项目(81360524)
广西高校中药提取纯化与质量分析重点实验室(桂教科研[2014]6号)
国家中医药管理局科研三级实验室中(壮)药化学与质量分析实验室(国中医药发2009[21]号)。
关键词
大承气汤
大黄
泻下作用
Dachengqi decoction
rhubarb
purgative action
