摘要
糖尿病是以长期高血糖伴或不伴进展性血管病变为特征的内分泌系统疾病,涉及全身并发症,主要表现为大血管病变及微血管病变,是糖尿病致死、致残的首要原因,然而其发病机制尚未完全阐明。内皮细胞是维持血管稳态的重要组成部分,内皮功能障碍是糖尿病血管并发症的始动或促进因素,而线粒体功能紊乱在血管内皮细胞功能紊乱的病理过程中发挥重要作用。近年来,线粒体-血管内皮功能的机制研究以及药物开发成为糖尿病防治的热点。该文主要阐述了线粒体功能障碍与糖尿病血管并发症的关系,旨在为相关药物开发以及临床诊治提供参考。
Diabetes is an endocrine disease characterized by long-term hyperglycemia with or without progressive vascular disease,involving systemic complications,mainly reflected in macroangiopathy and microangiopathy,which are the leading cause of death and disability of diabetes.However,its pathogenesis has not yet been fully clarified.Endothelial cells are an important part of maintaining vascular homeostasis,and endothelial dysfunction is the initiator or promoter of diabetic vascular complications.Mitochondrial dysfunction also plays an important role in the pathological process of vascular endothelial cell dysfunction.In recent years,researches of the mechanism of mitochondria-vascular endothelial function and the drug development have become a hot topic in prevention and treatment of diabetes.The present paper mainly expounds the relationship of mitochondrial dysfunction to vascular complications of diabetes,aiming to provide the basis for drug development and clinical diagnosis and treatment.
作者
白春昀
翁稚颖
肖创
贺源
刘伟军
郑昌博
陈晨
杨为民
Bai Chun-Yun;Weng Zhi-Ying;Xiao Chuang;He Yuan;Liu Wei-Jun;Zheng Chang-Bo;Chen Chen;Yang Wei-Min(School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming 650500,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2020年第3期323-329,共7页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金(81560589)
云南省科技厅联合基金(2018FE001-026)。
关键词
线粒体功能障碍
糖尿病
血管并发症
mitochondrial dysfunction
diabetes
vascular complication
