摘要
随着分子生物学和免疫学的发展,源自中枢组织的P物质(SP)因其广泛分布于人体各个组织而成为研究的热点。SP主要通过与其特异性受体神经激肽1受体(NK-1)结合而具有多种生物学活性,比如诱导炎症环境,促进肿瘤细胞的神经向性,诱导肿瘤细胞的增殖、迁移及促进胰岛素抵抗,上述机制与子宫内膜癌的发病及预后关系密切,可作为临床诊治子宫内膜癌的一个新靶点。因此,本文就该因子的生物学功能、在肿瘤方面的作用及其与子宫内膜癌的关系进行综述。
With the development of molecular biology and immunology,substance P(SP)derived from central tissues has become a research focus due to its widespread distribution in various human tissues.SP mainly has a variety of biological activities by binding to its specific receptor neurokinin 1 receptor(NK-1),such as inducing an inflammatory environment,promoting the neurotropy of tumor cells,inducing the proliferation,migration and promotion of tumor cells Insulin resistance,the above mechanism is closely related to the incidence and prognosis of endometrial cancer,and may become a new target for clinical diagnosis and treatment of endometrial cancer.This article reviews the biological function of the factor,its role in tumors,and its relationship with endometrial cancer.
作者
谭晓瑜
黄金智
赖锦胜
宋硕
陈国通
郑楚丽
陈智丹
TAN Xiao-yu;HUANG Jin-zhi;LAI Jin-sheng;SONG Shuo;CHEN Guo-tong;ZHENG Chu-li;CHEN Zhi-dan(Guangdong Medical University,Zhanjiang 524001,Guangdong,China;Department of Obstetrics and Gynecology,the Affiliated Hospital of Guangdong Medical University,Zhanjiang 524002,Guangdong,China)
出处
《医学信息》
2020年第7期29-32,共4页
Journal of Medical Information
基金
广东省自然科学基金项目(编号:2017A030313559)。
