摘要
目的探讨扩散峰度成像(DKI)评估血压控制正常的高血压患者脑实质微结构改变的价值。方法对血压控制在正常范围的22例原发性高血压患者(观察组)及健康志愿者19名(对照组)行MR DKI检查,测量并比较2组各脑区平均扩散峰度(MK)、峰度各向异性(KA)、轴向峰度(AK)及径向峰度(RK)。结果观察组右额叶、右内囊膝及右小脑MK值均低于对照组,右顶叶MK值高于对照组(P均<0.05);脑桥KA值低于对照组(P<0.05);左顶叶、右苍白球AK值低于对照组,左红核、右小脑及脑桥AK值高于对照组(P均<0.05);右内囊膝、右小脑及左枕叶RK值低于对照组,右壳核RK值高于对照组(P均<0.05)。结论DKI能够评估血压控制正常的高血压患者脑实质微结构改变。
Objective To investigate the application value of diffusion kurtosis imaging(DKI)for evaluating brain parenchyma microstructures changes in hypertensive patients with normal blood pressure control.Methods Totally 22 patients with primary hypertension with blood pressure controlled in normal range were enrolled in observation group,while 19 healthy volunteers were selected as control group.DKI was performed in all subjects,and the mean kurtosis(MK),kurtosis anisotropy(KA),axial kurtosis(AK)and radial kurtosis(RK)of each brain area were measured and compared between the two groups.Results MK values in right frontal lobe,right inner capsule knee and right cerebellum of observation group were lower than that of control group,whereas in right parietal lobe was higher than in control group(all P<0.05).The pontine KA value in observation group was lower than that in control group(P<0.05).AK values of left parietal lobe and right pallidum of observation group were lower than that in control group,of left red nucleus,right cerebellum and pontine were higher than that in control group(all P<0.05).The values of RK in right inner capsule knee,right cerebellum and left occipital lobe in observation group were lower than that in control group,and of right putamen was higher than that in control group(all P<0.05).Conclusion DKI can be used to monitor changes of brain parenchyma microstructures in hypertensive patients with normal blood pressure control.
作者
王伟新
刘明
张秋奂
杨柳青
陈虹
李杰
郭鹏德
WANG Weixin;LIU Ming;ZHANG Qiuhuan;YANG Liuqing;CHEN Hong;LI Jie;GUO Pengde(Department of Radiology,Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China)
出处
《中国介入影像与治疗学》
北大核心
2020年第4期224-227,共4页
Chinese Journal of Interventional Imaging and Therapy
关键词
高血压
弥散峰度成像
磁共振成像
脑实质微结构
hypertension
diffusion kurtorsis imaging
magnetic resonance imaging
cerebral microstructure
