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血清miR-192表达与晚期胃癌化疗效果的关系 被引量:2

Relationship between serummiR-192 expression and chemotherapy effect in advanced gastric cancer
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摘要 探讨晚期胃癌患者血清miR-192表达与化疗疗效的关系。选取2011年1月—2018年2月在我院治疗的晚期胃癌患者89例接受含铂方案化疗,检测患者血清miR-192表达水平。89例患者中,无完全缓解(CR)患者,部分缓解(PR)患者20例(22.47%),疾病稳定(SD)患者49例(55.06%),疾病进展(PD)患者20例(22.47%)。CR+PR患者血清miR-192相对表达量为(0.151±0.052),明显高于SD+PD患者(P<0.05);临床分期Ⅳ期患者血清miR-192相对表达量为(0.074±0.030),明显低于Ⅲ期患者(P<0.05)。Logistic回归分析显示病理类型、临床分期、ECOG评分、miR-192表达是晚期胃癌患者化疗效果的影响因素(OR=3.071、3.550、2.457和0.693,P<0.05)。晚期胃癌患者血清miR-192表达与化疗疗效、临床分期有一定关系。
作者 郭鹏 GUO Peng
出处 《中国现代普通外科进展》 CAS 2020年第2期145-146,149,共3页 Chinese Journal of Current Advances in General Surgery
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