摘要
提出了一种利用组织的光声、光热效应对早期乳腺癌检测和治疗的方法。采用蒙特卡罗仿真,模拟了近红外光到达人体乳腺组织时的能量沉积分布,仿真了由此产生的压力信号;再在肿瘤组织中加入了纳米金粒子,使近红外光在人体乳腺中产生的能量沉积聚集到肿瘤附近,从而在特定部位产生较高的温度。结果表明,光声信号的探测能有效的定位组织中肿瘤的位置,确定肿瘤大小、形状等特性,且在加入半径50 nm的纳米金粒子后,对靶组织的加热效率得到了提升,可提高特定组织光照后的温度,且对周边组织影响较小,基本可达到对早期乳腺癌的检测和治疗效果。
In this paper, we propose a method to detect and treat early breast cancer using tissue photoacoustic and photothermal effects. In the study, we simulated the energy deposition distribution of near infrared light when it reached human breast tissue by Monte Carlo simulation, and simulated the pressure signal generated by it. Then we added nano-gold particles to the tumor tissue, which made the energy deposition of near infrared light in human breast accumulate near the tumor, thus in a specific way. Higher temperatures are produced at the site. The results show that the detection of photoacoustic signals can effectively locate tumors in tissues, determine the size and shape of tumors, and increase the heating efficiency of target tissues by adding gold nanoparticles with a radius of 50 nm. It can improve the temperature of specific tissues after illumination, and has little influence on surrounding tissues. It can basically achieve the detection and treatment of early breast cancer.
作者
王文龙
武京治
王艳红
Wang Wenlong;Wu Jingzhi;Wang Yanhong(School of Information and Communication Engineering,North University of China,Taiyuan 030051,China)
出处
《电子测量技术》
2020年第2期172-176,共5页
Electronic Measurement Technology
关键词
光声检测
光热效应
光热疗法
蒙特卡罗仿真
早期乳腺癌检测治疗
photoacoustic detection
photothermal effect
photothermal therapy
Monte Carlo simulation
early breast cancer detection and treatment
