摘要
目的:探讨革兰氏阴性菌血流感染病原学特征、耐药情况及与降钙素的相关性.方法:收集2017年1月~2019年1月在我院住院患者的血液标本861份,分离革兰氏阴性菌,分析病原菌分布情况,采用最低抑菌浓度法检测病原菌的耐药性;检测所有血液标本降钙素原含量,并分析其与革兰氏阴性菌感染的相关性.结果:1861例血标本中共分离129株革兰氏阴性菌,阳性率为14.98%,;大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌、铜绿假单胞菌、鲍曼不动杆菌主要分布在ICU;大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌、铜绿假单胞菌、鲍曼不动杆菌对抗菌素均存在不同程度的耐药率,大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌、铜绿假单胞菌、鲍曼不动杆菌对亚胺培南的耐药率较高;降钙素原含量与革兰氏阴性菌感染呈正相关(r=0.58,P=0.000).结论:血流感染中革兰氏阴性菌以大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌、铜绿假单胞菌、鲍曼不动杆菌为主,其对抗生素存在不同程度的耐药率,降钙素原含量与革兰氏阴性菌感染呈正相关.
Objective:To explore bloodstream infection pathogenic features and drug resistance of Gram-negative bacteria and its correlation with calcitonin(CT).Methods:861 blood samples were collected from inpatients in the hospital from January 2017 to January 2019.The Gram-negative bacteria was isolated.The distribution of pathogens was analyzed.The drug resistance of pathogens was detected by minimal inhibitory concentration(MIC)method.Procalcitonin(PCT)content in all blood samples was detected.And its correlation with Gram-negative bacteria infection was analyzed.Results:Of 1861 blood samples,there were 129 strains of Gram-negative bacteria isolated,with positive rate of 14.98%.Escherichia coli,Klebsiella pneumoniae,Enterobacter cloacae,Pseudomonas aeruginosa and Acinetobacter baumannii were mainly distributed in ICU.The above pathogens were of drug resistance to antibiotics at different degrees.And drug resistance rates of the above pathogens were relatively higher to iniipenem.PCT content was positively correlated with Gram-negative bacteria infection(r=0.58,P=0.000).Conclusion:In bloodstream infection,Gram-negative bacteria is mainly on Escherichia coli,Klebsiella pneumoniae,Enterobacter cloacae,Pseudomonas aeruginosa and Acinetobacter baumannii,which are of dnig resistance rates to antibiotics at different degrees.PCT content is positively correlated with Gram-negative bacteria infection.
作者
张现莉
ZHANG Xian-li(Department of Clinical Laboratory,Pingyi County People's Hospital,Shandong Linyi 273300)
出处
《医学检验与临床》
2019年第11期19-22,共4页
Medical Laboratory Science and Clinics
关键词
革兰氏阴性菌
血流感染
病原学特征
耐药性
Gram-negative bacteria
Bloodstream infection
Pathogenic feature
Drug resistance
