摘要
冠状病毒是一类在自然界中广泛存在的单链RNA病毒,21世纪头二十年由冠状病毒引起的传染病已在世界范围内引起3次较大规模的流行,加强对冠状病毒的研究势在必行。该文主要以SARS冠状病毒(SARS-CoV)、中东呼吸综合征冠状病毒(MERS-CoV)以及最近在全球爆发的新型冠状病毒(SARS-CoV-2/2019-nCoV)为例,总结了这些冠状病毒在结构、基因、来源、传染力和致病性等方面的异同,基于实验研究和临床报道,从细胞因子风暴、中性粒细胞异常增多、淋巴细胞亚群失衡等方面阐述了新型冠状病毒肺炎发病的免疫失衡现象以及相应的干预策略,并提出后续展望,为新型冠状病毒肺炎的防治提供新策略和新思路。
Coronaviruses,a large family of single-stranded RNA viruses,are responsible for three large-scale worldwide epidemics in the first two decades of the 21st century.Thus,it is imperative to strengthen the research on coronaviruses.This review summarizes the similarities and differences of three coronaviruses(including SARS-CoV,MERS-CoV,SARS-CoV-2)in structure,gene,origin,infectiousness and pathogenicity.Then,the review illuminates immune response mechanism and intervention strategies in terms of cytokine storm,neutrophil extracellular traps,imbalance of lymphocyte subsets in patients infected with coronaviruses based on experimental studies and clinical cases reports.Finally,new therapeutic strategies and ideas are put forward for the prevention and treatment of coronavirus disease 2019(COVID-19).
作者
杨晨茜
瞿娇
刘怡彤
孟思伟
王冰琳
冯美卿
孙洋
YANG Chen-xi;QU Jiao;LIU Yi-tong;MENG Si-wei;WANG Bing-lin;FENG Mei-qing;SUN Yang(State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, China;School of Pharmacy, Fudan University, Shanghai 201203, China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2020年第4期445-453,共9页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81872877,91853109,81673436)
浙江大学新型冠状病毒肺炎应急科研专项(No 2020XGZX027)。
