摘要
Long non-coding RNAs(IncRNAs)have critical roles in the development of many diseases including kidney disease.An increasing number of studies have shown that IncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes,including acute kidney injury(AKI),chronic kidney disease(CKD),and renal cell carcinoma(RCC).Understanding the roles of IncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities in the clinic.This review provides an overview of IncRNA characteristics,biological function and discusses specific studies that provide insight into the function and potential application of IncRNAs in kidney disease treatment.
基金
This work was supported by grants from the Guangzhou Science,Technology and Innovation Commission(201806010123)
Kelin Young Talents Program of the First Affiliated Hospital of Sun Yat-sen University,National Key R&D Program of China(2016YFC0906101)
Operational Grant of Guangdong Provincial Key Laboratory(2017B030314019)
Guangdong Provincial Programme of Science and Technology(2017A050503003),(2017B020227006)
Guangzhou Municipal Programme of Science and Technology(201704020167).
