摘要
目的本研究旨在探讨全身免疫炎症指数(systemic immune-inflammation index,SII)与急性脑梗死(acute cerebral ischemic stroke,AIS)患者发生卒中相关性肺炎(stroke-associated pneumonia,SAP)的相关性。方法前瞻性纳入2015年1月~2016年12月就诊于郑州大学第一附属医院发病24 h内的AIS患者,收集人口学特征、血常规结果,计算SII值,使用单因素及多因素logistic回归分析确定SII与SAP的关系,应用受试者工作(receiver operating characteristic,ROC)曲线评价SII对SAP的预测价值。结果共纳入641例AIS患者,未发生SAP 591例(92.20%),发生SAP有50例(7.80%);单因素分析结果显示SAP组SII值高于非SAP组[564.00(385.71,856.46)vs 1191.33(843.71,2120.91),P<0.001];依据SII四分位数将研究对象分组,多因素分析结果显示高四分位数组AIS患者发生SAP的风险增加8.083倍,差异有统计学意义(P<0.001);受试者工作(ROC)曲线分析显示,曲线下面积为0.781(P<0.0001),SII最佳截断点为810.84时,其预测AIS患者发生SAP的敏感度为80.0%,特异度为71.9%。结论SII是AIS患者发生SAP的潜在独立危险因素。
Objective to investigate the relationship between systemic immune-inflammation index(SII)and stroke-associated pneumonia(SAP)in acute ischemic stroke(AIS)patients.Methods AIS patients prospectively admitted to the First Affiliated Hospital of Zhengzhou University from January 2015 to December 2016.We recorded demographic characteristics and its blood routine results to calculate SII.Univariate and multivariate logistic regression analysis was used to assess the relationship between SII and SAP.The receiver operating characteristic(ROC)curve analysis was used to evaluate the predictive value of SII to SAP.Results A total of 641 patients were included which 50(7.80%)had SAP.SII was higher in the SAP group[564.00(385.71,856.46)vs 1191.33(843.71,2120.91),P<0.001].Multivariable analysis showed the risk of SAP in the highest quartile group was increased by 8.083 times.the difference was statistically significant(95%CI 2.673~24.442;P<0.001).The receiver operating characteristic(ROC)curve analysis showed that the area under the curve of SII was 0.781(P<0.0001).the cut-off value for predicting SAP was 810.84,the sensitivity and specificity was 80.0%and 71.9%.Conclusion SII was an potential independent risk factor for acute ischemic stroke(AIS)patients to predict SAP.
作者
曾喜
李屾
刘红兵
李友凤
孙文先
王台
吴军
孙石磊
李玉生
宋波
许予明
ZENG Xi;LI Shen;LIU Hongbing(Department of Neurology,The First Affiliated Hospital of Zhengzhou Medical University,Zhengzhou 450052,China)
出处
《中风与神经疾病杂志》
CAS
2020年第3期222-226,共5页
Journal of Apoplexy and Nervous Diseases
基金
国家自然科学基金面上项目(81571158)
郑州大学第一附属医院院内基金(2017-BSTDJJ-01)。
关键词
全身免疫炎症指数
急性脑梗死
卒中相关性肺炎
Systemic immune-inflammation index
Acute cerebral ischemic stroke
Stroke-associated pneumonia
