摘要
目的:探讨低频重复经颅磁刺激(rTMS)联合利培酮对精神分裂患者的妄想症状的疗效及不良反应。方法:选取2018年4月-2019年6月本院有妄想症状的精神分裂症患者88例,按随机数字表法分为研究组和对照组,各44例。两组均采用利培酮治疗,研究组予以低频(1 Hz)rTMS治疗,对照组予以假性rTMS治疗。比较两组阳性和阴性症状量表(PANSS)、妄想特质评定量表(CDRS)评分及不良反应量表(TESS)评分。结果:治疗后,两组PANSS各因子评分、PANSS总分及CDRS分均低于治疗前(P<0.05);治疗后,研究组PANSS各因子评分、PANSS总分及CDRS分均低于对照组(P<0.05)。两组TESS评分比较,差异无统计学意义(P>0.05)。结论:低频rTMS联合利培酮治疗精神分裂症可更好地改善患者伴发的妄想症状,不良反应少,值得临床应用。
Objective: To investigate the efficacy of low frequency repetitive transcranial magnetic stimulation(rTMS) combined with Risperidone in the treatment of delusional symptoms and adverse reactions in schizophrenic patients. Method: From April 2018 to June 2019, 88 schizophrenic patients with delusional symptoms in our hospital were selected. They were divided into study group and control group according to the random number table method, 44 cases in each group. Both groups were treated with Risperidone, and the study group was treated with low frequency(1 Hz) rTMS, the control group was treated with pseudo rTMS. Positive and negative syndrome scale(PANSS), characteristics of delusions rating scale(CDRS) and treatment emergent symptom scale(TESS) scores were compared between the two groups. Result: After treatment, the all factor and total score of PANSS, CDRS scores of the two groups were lower than those before treatment(P<0.05). The all factor and total score of PANSS, CDRS scores of the study group were lower than those of the control group(P<0.05). There was no significant difference in TESS score between the two groups(P>0.05). Conclusion: Low frequency rTMS combined with Risperidone in the treatment of schizophrenia can better improve the patients with delusional symptoms, less adverse reactions, worthy of clinical application.
作者
吕爽
张献强
刘佳
高海龙
崔红梅
李丹
LYU Shuang;ZHANG Xianqiang;LIU Jia;GAO Hailong;CUI Hongmei;LI Dan(Psychiatric Hospital of Guangzhou Civil Administration Bureau,Guangzhou 510000,China)
出处
《中国医学创新》
CAS
2020年第2期109-112,共4页
Medical Innovation of China
基金
广州市科技计划项目(201804010122)。
