摘要
目的:探讨疏风解毒胶囊对慢性阻塞性肺疾病急性加重期(AECOPD)的作用及其相关作用机制。方法:选取2018年5-8月本院收治的AECOPD患者90例,随机分为常规治疗组和疏风解毒胶囊组,每组45例。常规治疗组给予常规治疗,疏风解毒胶囊组在常规治疗的基础上给予疏风解毒胶囊,选取同期30例来本院体检的健康者为对照组。比较各组血清中丙二醛(MDA)、一氧化氮(NO)含量及过氧化氢酶(CAT)、过氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH)、总一氧化氮合酶(eNOS)活性;比较疏风解毒胶囊组和常规治疗组治疗前后呼出气一氧化氮(FeNO)水平和肺功能水平。结果:三组MDA含量、CAT、SOD以及GSH活性比较,差异均有统计学意义(P<0.05)。疏风解毒胶囊组的MDA含量明显高于对照组,CAT、SOD以及GSH活性均明显低于对照组(P<0.05);常规治疗组MDA含量显著高于疏风解毒胶囊组,CAT、SOD以及GSH活性均明显低于疏风解毒胶囊组(P<0.05)。三组NO含量和eNOS活性比较,差异均有统计学意义(P<0.05)。疏风解毒胶囊组NO含量和eNOS活性均显著高于对照组(P<0.05);常规治疗组NO含量和eNOS活性均显著高于疏风解毒胶囊组(P<0.05)。治疗前,常规治疗组和疏风解毒胶囊组FeNO水平均高于对照组,差异均有统计学意义(P<0.05);治疗后,常规治疗组和疏风解毒胶囊组FeNO水平均明显低于治疗前,差异均有统计学意义(P<0.05)。治疗后,两组FEV1占预计值百分比、FEV1/FVC水平均高于治疗前,且疏风解毒胶囊组均高于常规治疗组,差异均有统计学意义(P<0.05)。结论:疏风解毒胶囊可显著改善AECOPD引起的氧化应激反应,能有效抑制患者气道炎症和改善AECOPD患者的肺功能。
Objective:To explore the effect of Shufeng Jiedu Capsule on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its mechanism.Method:A total of 90 patients with AECOPD admitted to our hospital from May to August 2018 were selected.They were randomly divided into conventional treatment group and Shufeng Jiedu Capsule group,45 cases in each group.The conventional treatment group was given conventional treatment,the Shufeng Jiedu Capsule group was given Shufeng Jiedu Capsule on the basis of conventional treatment.30 healthy patients who came to our hospital for physical examination during the same period were selected as the control group.The contents of malondialdehyde (MDA),nitric oxide (NO),catalase (CAT),superoxide dismutase (SOD),glutathione peroxidase (GSH) and total nitric oxide synthase (eNOS) in serum of each group were compared.The levels of exhaled nitric oxide (FeNO) and lung function were compared between the Shufeng Jiedu Capsule group and the conventional treatment group before and after treatment.Result:The MDA content,CAT,SOD and GSH activity in three groups were compared,the differences were statistically significant (P<0.05).The content of MDA in the Shufeng Jiedu Capsule group was significantly higher than that in the control group,the activity of CAT,SOD and GSH were significantly lower than those of the control group (P<0.05).MDA content in the conventional treatment group was significantly higher than that in the Shufeng Jiedu Capsule group,the activity of CAT,SOD and GSH were significantly lower than those of Shufeng Jiedu Capsule group (P<0.05).The NO content and eNOS activity in three groups were compared,the differences were statistically significant (P<0.05).NO content and eNOS activity in Shufeng Jiedu Capsule group were significantly higher than those in control group (P<0.05).NO content and eNOS activity in the conventional treatment group were significantly higher than those in the Shufeng Jiedu Capsule group (P<0.05).Before the treatment,FeNO levels in the conventional treatment group and the Shufeng Jiedu Capsule group were higher than those in the control group,the differences were statistically significant (P<0.05).After treatment,FeNO levels in the conventional treatment group and the Shufeng Jiedu Capsule group were significantly lower than those before treatment,the differences were statistically significant (P<0.05).After treatment,the predicted value of FEV1% pred and the level of FEV1/FVC in both groups were higher than those before treatment,and the levels of Shufeng Jiedu Capsule group were higher than those in the conventional treatment group,the differences were statistically significant (P<0.05).Conclusion:Shufeng Jiedu Capsule can significantly improve oxidative stress response caused by AECOPD,effectively inhibit airway inflammation and improve lung function in patients with AECOPD.
作者
朱静
徐维国
ZHU Jing;XU Weiguo(Center Hospital of Mianyang,Mianyang 621000,China)
出处
《中国医学创新》
CAS
2020年第3期8-12,共5页
Medical Innovation of China
基金
中国宋庆龄基金会项目(2018MZFS-046)。
关键词
慢性阻塞性肺疾病
疏风解毒胶囊
气道炎症
氧化应激反应
Chronic obstructive pulmonary disease
Shufeng Jiedu Capsule
Airway inflammation
Oxidative stress
