摘要
目的探讨高敏C反应蛋白(hs-CRP)联合B型钠尿肽(BNP)检测对慢性心力衰竭诊断、治疗及预后评估的作用。方法选取2015年1月~2016年1月在汉川市人民医院治疗的慢性心力衰竭患者120例作为研究组,同期体检的健康成人60例作为对照组,比较两组血清hs-CRP和BNP水平及研究组不同时期上述两项指标。结果治疗前研究组患者血清hs-CRP和BNP水平显著高于对照组,且患者心功能分级越高,二者的水平越高(P <0.05);研究组治疗48 h及出院时hs-CRP和BNP水平比治疗前明显降低(P <0.05);与单独检测相比,hs-CRP和BNP联合检测具有更高的敏感度和特异性(P <0.05);研究组发生心脏事件患者的hs-CRP和BNP水平显著高于未发生心脏事件的(P <0.05)。结论 hs-CRP和BNP联合检测对慢性心力衰竭的诊断、治疗及预后评估具有较高的临床价值,优于单独检测。
Objective To explore the clinical value of detection of high sensitivity C-reactive protein(hs-CRP) combined with B-type natriuretic peptide(BNP) in the diagnosis and prognostic evaluation of chronic heart failure.Methods 120 patients with chronic heart failure were selected as the research group from January 2015 to January 2016 in Hanchuan People’s Hospital.At the same time,60 healthy adults were selected as the control group.The levels of serum hs-CRP and BNP were measured.Results The levels hs-CRP and BNP in the research group were significantly higher than those in the control group,and increased with the increase of cardiac function grade before treatment(P < 0.05).At 48 hours after treatment and at discharge,the levels of hs-CRP and BNP were significantly lower than before treatment in the research group(P < 0.05).The sensitivity and specificity of combined detection of hs-CRP and BNP were significantly higher than those of single detection(P < 0.05).The levels of hs-CRP and BNP in patients with cardiac events were significantly higher than those without cardiac events(P < 0.05).Conclusion Combined detection of hs-CRP and BNP is more valuable than single detection in the diagnosis and prognostic evaluation of patients with chronic heart failure.
作者
李琼
王磊
高波
Li Qiong;Wang Lei;Gao Bo(Department of CardiologyⅡ,Hanchuan People's Hospital,Hanchuan 431600,China)
出处
《国际老年医学杂志》
2020年第2期90-91,99,共3页
International Journal of Geriatrics
关键词
高敏C反应蛋白
B型钠尿肽
联合检测
慢性心力衰竭
临床价值
预后评估
High sensitive C-reactive protein
B-type natriuretic peptide
Combined detection
Chronic heart failure
Clinical value
Prognostic evaluation
