摘要
目的探讨和比较两种生物免疫诱导剂抗人T细胞兔免疫球蛋白(anti-human T lymphocyte rabbit immunoglobulin,ATG)与巴利昔单抗在肾移植术后对C反应蛋白(C reactive protein,CRP)与降钙素原(procalcitonin,PCT)等炎症指标的影响。方法回顾性分析本院2016年1月—2016年12月使用了ATG或巴利昔单抗进行免疫诱导治疗的115例肾移植患者资料。比较分析肾移植术后1~4 d、5~7 d及>7 d三个阶段的CRP、PCT水平等相关指标。结果肾移植手术后两组的CRP和PCT均先升高后归正。在对CRP影响上,仅在1~4 d这一阶段ATG组引起CRP较巴利昔单抗组高(P<0.05),在CRP归正时间上,两组也无显著差异(P>0.05)。在对PCT的影响上,ATG组与巴利昔单抗组相比,移植术后每个阶段的PCT值有显著差异(P<0.001),在归正时间上,两组也有显著差异,分别为(9.2±3.8)d和(4.1±2.5)d。结论在肾移植中,ATG组显著增加PCT并延长其归正时间。在肾移植围术期评估感染和排斥反应时,必须考虑生物免疫诱导剂对炎症指标的影响。
Objective To investigate and compare the effects of two kinds of biological immune inducers,anti-human T-cell rabbit immunoglobulin(ATG)and baliximab,on inflammatory markers such as C reactive protein(CRP)and procalcitonin(PCT)after kidney transplantation.Methods The data of 115 renal transplant patients treated with ATG or baliximab from January 2016 to December 2016 were retrospectively analyzed.The levels of CRP and PCT in the three stages of 1~4 days,5~7 days and>7 days after renal transplantation were compared and analyzed..Results CRP and PCT in both groups increased at first and then returned to normal after renal transplantation.Regarding the impact of CRP,ATG group caused higher CRP than baliximab group in the stage of 1~4 day(P<0.05),and there was no significant difference in recovery time between the two groups(P>0.05).When comparing with baliximab group,there were significant differences in PCT value at each stage after transplantation in ATG group(P<0.001).There was also significant difference in the time of normalization between the two groups,(9.2±3.8)days and(4.1±2.5)days,respectively.Conclusion In renal transplantation,PCT was significantly increased in ATG group and its recovery time was prolonged.The effect of biological immune inducers on inflammatory markers must be considered in perioperative evaluation of infection and rejection in renal transplantation.
作者
马葵芬
钟琳
余献平
彭文瀚
吴建永
卢晓阳
Ma Kuifen;Zhong Lin;Yu Xianping;Peng Wenhan;Wu Jianyong;Lu Xiaoyang(Department of Pharmacy,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310000,Zhejiang,China;Department of Pharmacy,Xiaoshan Hospital of Traditional Chinese Medicine,Hangzhou 311200,Zhejiang,China;Department of Nephrology,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,Zhejiang,China)
出处
《实用器官移植电子杂志》
2020年第1期33-36,共4页
Practical Journal of Organ Transplantation(Electronic Version)
基金
浙江省医药卫生科技项目(2018RC031)
浙江省自然科学基金(LY19H310008)。
关键词
肾移植
生物免疫诱导剂
抗人T细胞兔免疫球蛋白
巴利昔单抗
Renal transplantation
Biological immune inducer
Anti-human T-cell rabbit immunoglobulin
Baliximab
