摘要
目的探讨血清中尿素、胱抑素C、尿酸、同型半胱氨酸、钙离子、镁离子与妊娠高血压综合征(pregnancyinduced hypertension syndrome,PIH)病情发展的关系。方法选择我院收治的妊娠高血压综合征患者83例为研究对象,根据发病程度分为轻度、中度、重度;另选取同期产检的健康孕妇83例为对照组。对所有孕妇进行血清尿素、胱抑素C、尿酸、同型半胱氨酸、钙离子、镁离子检测,并比较分析这几种检测指标水平与妊娠高血压综合征病情发展的关系。结果实验组血清尿素、胱抑素C、尿酸、同型半胱氨酸水平高于对照组,钙离子、镁离子水平低于对照组,差异有统计学意义(P<0.05);PIH患者血清尿素、胱抑素C、尿酸、同型半胱氨酸水平轻度组<中度组<重度组,钙离子、镁离子水平轻度组>中度组>重度组,差异有统计学意义(P<0.05);尿素、胱抑素C、尿酸、同型半胱氨酸水平与PIH病情的严重程度呈正相关(P<0.05),钙离子、镁离子水平与PIH病情的严重程度呈负相关(P<0.05)。结论血清尿素、胱抑素C等指标水平对PIH病情的发展有预测作用,动态监测这些指标有利于PIH的辅助诊断、早期治疗、评估病情程度及预后评价。
Objective To investigate the relationship between serum urea, cystatin C, uric acid, homocysteine, calcium ion and magnesium ion and the pathogenesis of pregnancy-induced hypertension syndrome(PIH). Methods Eightythree patients with pregnancy-induced hypertension syndrome admitted to our hospital were enrolled as the experimental group and classified as the mild, moderate and severe groups according to the severity of disease. Another 83 healthy pregnant women who received antenatal care during the same period were selected as the control group. Serum urea, cystatin C, uric acid, homocysteine, calcium ion and magnesium ion were detected in all pregnant women. The relationship between the levels of detected indicators and the pathogenesis of pregnancy-induced hypertension syndrome was analyzed. Results The levels of serum urea, cystatin C, uric acid and homocysteine in the experimental group were higher than those in the control group. The levels of calcium ion and magnesium ion were lower than those in the control group. The differences were statistically significant(P<0.05). The levels of urea, cystatin C, uric acid and homocysteine were shown as mild group<moderate group<severe group, while the levels of calcium ion and magnesium ion were mild group>moderate group>severe group among PIH patients. The differences were statistically significant( P<0.05).The levels of urea, cystatin C, uric acid and homocysteine were positively correlated with the severity of PIH(P<0.05),while the levels of calcium ion and magnesium ion were negatively correlated with the severity of PIH(P<0.05). Conclusion Serum urea, cystatin C and other indicators have a predictive effect on the pathogenesis of PIH. Dynamic monitoring of these indicators is beneficial to the auxiliary diagnosis, early treatment, evaluation of disease severity and prognosis of PIH.
作者
李贤见
LI Xianjian(Clinical Laboratory,the People's Hospital of Kaizhou District in Chongqing,Chongqing405499,China)
出处
《中国现代医生》
2020年第3期148-151,共4页
China Modern Doctor
关键词
尿素
胱抑素C
妊娠高血压综合征
病情程度
关系
Urea
Cystatin C
Pregnancy-induced hypertension syndrome
Severity of disease
Relationship
