摘要
目的研究类风湿关节炎(rheumatoid arthritis,RA)病人抗核抗体(antinuclear antibody,ANA)阳性的比例及类型,进一步探讨ANA阳性对应的相应抗体以及RA患者ANA与血清类风湿因子(rheumatoid factor,RF)和抗环瓜氨酸肽抗体(anti-cyclic citrullinated peptide antibody,ACPA)水平的关系,从而对RA患者的病因进行研究。方法选取山东中医药大学附属医院风湿免疫科的病人462例。其中RA患者342例,骨关节炎患者120例。分别检测两组患者的ANA阳性率、ANA类型和ANA谱以及ANA阳性率与RF和ACPA水平的关系。结果342例RA患者中,ANA阳性的比例为64.04%,而骨关节炎患者ANA阳性率仅为4.17%,二者相比差异有统计学意义(χ^2=127.47,P<0.01)。RA患者的ANA阳性类型以核颗粒型和核均质型为主(占71.69%)。研究RA患者ANA阳性率与血清RF和ACPA水平的关系发现血清RF和ACPA水平高的患者ANA阳性率要高于RF和ACPA水平低的病人(χ^2=46.33,P<0.05)。结论RA患者的ANA阳性率明显高于正常人,其类型以核颗粒型和核均质型为主。RA的ANA阳性率与血清RF和ACPA的水平呈正相关。抗核抗体在RA的发病中可能发挥着重要的作用。
Objective In order to make the etiology of rheumatoid arthritis( RA) clear,studied the positive rate of antinuclear antibody( ANA),the ANA pattern and the related antibody in rheumatoid patients. Then further studied the relationship between the positive rate of ANA and the serum level of rheumatoid factor( RF) and anti-cyclic citrullinated peptide antibody( ACPA) in rheumatoid patients. Methods 462 patients from Department of Rheumatology,Affiliated Hospital of Shandong University of Tranditional Chinese Medicine were selected. 342 patients of them were diagnosed with rheumatoid arthritis( case group). 120 patientswere diagnosed with osteoarthritis( control group). The positive rate of ANA,the ANA pattern,ANA spectrum and the relationship between the positive rate of ANA and the serum level of RF an ACPA were observed. Results The positive rate of ANA in 342 rheumatoid patients was 64. 04%,and the positive rate of ANA in 120 osteoarthritis patients was 4. 17%. There was statistical significance between the two groups( χ~2= 127. 47,P < 0. 01). The ANA patternin rheumatoid patients mainly included nuclear granule type and nuclear homogeneity type( accounting for 71. 69%). Then found the positive rate of ANA in the patients with higher serum level of RF or ACPA was higher than that in patients with lower serum level of RF or ACPA( χ~2= 46. 33,P < 0. 05). Conclusion The positive rate of ANA in rheumatoid patients was significantly higherthan that in normal person. The ANA pattern in these patients mainly included nuclear granule type and nuclear homogeneity type. The positive rate of ANA in RA patients was in direct proportion to their serum level of RF and ACPA. So ANA may play an important role in development of RA.
作者
刘卫霞
庞爱梅
郭绪晓
张恒
LIU Wei-xia;PANG Ai-mei;GUO Xu-xiao;ZHANG Heng(Department of Clinical Laboratory,Affiliated Hospital of Shandong University of Tranditional Chinese Medicine,Jinan 250011,China)
出处
《现代检验医学杂志》
CAS
2020年第1期65-66,70,共3页
Journal of Modern Laboratory Medicine
基金
山东省中医药科技发展计划项目(2013-069)。
关键词
类风湿关节炎
抗核抗体
类风湿因子
抗环瓜氨酸肽抗体
rheumatoid arthritis
antinuclear antibody
rheumatoid factor
anti-cyclic citrullinated peptide antibody
