摘要
目的探讨人参汤的功效物质基础和作用机制。方法利用TCMSP平台检索人参汤4味中药人参、甘草,干姜,白术的化学成分和作用靶点,并根据口服生物利用度以及药物相似性对潜在的生物活性成分进行筛选。本研究采用David v6.8数据库对交集靶点进行GO功能富集分析和KEGG通路富集分析。结果共得出126个活性成分,对应81个靶点,与冠心病相关靶点18个,通过GO分析得出85条生物过程(BP,biological process)、10条细胞组分(CC,cellular component)、14条分子功能(MF,molecular function),通过KEGG通路富集得出23条信号通路。结论本研究结果初步分析人参汤防治疾病的分子机制,为进一步深入探讨其作用机制提供先导信息和基础。
Objective To explore the functional material basis and mechanism of Renshen Decoction. Methods The chemical components and targets of Radix Ginseng, Radix Glycyrrhizae, Rhizoma Zingiberis and Rhizoma Atractylodis Macrocephalae were retrieved by TCMSP platform, and the potential bioactive components were screened according to the oral bioavailability and drug similarity. In this study, David v6.8 database was used to conduct GO functional enrichment analysis and KEGG pathway enrichment analysis on intersection targets. Results 126 active components were obtained, corresponding to 81 targets, and 18 targets related to coronary heart disease. Through GO analysis, 89 biological processes(BP, biological process), 10 cellular components(CC, cellular component), and 14 molecular functions(MF, molecular function) were obtained. 23 signaling pathways were obtained by KEGG pathway enrichment.Conclusion The results of this study preliminarily analyzed the molecular mechanism of Renshen Decoction in the prevention and treatment of diseases, so as to provide pilot information and basis for further exploration of its mechanism of action.
作者
徐香梅
徐文华
杨文娜
陈旋
赵阳
赵新望
郑景辉
Xu Xiangmei;Xu Wenhua;Yang Wenna;Chen Xuan;Zhao Yang;Zhao Xinwang;Zheng Jinghui(Guangxi University of Traditional Chinese Medicine,Nanning 530001,China;Ruikang Hospital,Guangxi University of Traditional Chinese Medicine,Nanning 530001,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2019年第11期2318-2327,共10页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会基础研究项目(81660776):基于线粒体纸质-蛋白质组学的养心通脉有效部位方抗大鼠心肌缺血内灌注损伤机制的研究,负责人:郑景辉
广西自然科学基金项目(2016GXNSFAA380296):养心通脉有效部位方干预缺血再灌注损伤心肌细胞线粒体的脂质组学研究,负责人:郑景辉
研究生教育创新计划项目(YCSY2018034):neuregulin-1/ErbB通路在养心通脉有效部位方诱导骨髓间充质干细胞脑分化过程中的作用,负责人:徐文华。
关键词
人参汤
冠心病
系统药理学
蛋白相互作用
信号转导通路
Renshen Decoction
Coronary heart disease(CHD)
Systemic pharmacology
Protein interactions
Signal transduction pathways
