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观察重组人生长激素治疗特发性矮小症儿童的临床疗效及对胰岛素样生长因子的影响 被引量:13

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摘要 目的:观察在特发性矮小症儿童治疗中重组人生长激素的临床治疗效果及对胰岛素样生长因子所产生的影响。方法:选取2018年2月份~2019年2月份在本院进行特发性矮小症治疗的患儿,共98例,按照奇偶数字分组法,将抽到奇数的患儿分到对照组,将抽到偶数的患儿分到观察组,每组患儿各49例,对照组行常规治疗法,观察组行重组人生长激素治疗方法。结果:治疗后,观察组各项参数均优于对照组,BA无统计学差异,GV(生长速度)、PAH(预测成年身高)、Ht-SDSBA(身高标准差分值)、Ht-SDSca(身高标准差积分)之间差异显著(P<0.05)。观察组各项胰岛素生长因子水平均较对照组高,不良反应发生率观察组较对照组高,差异明显(P<0.05)。结论:在特发性矮小症儿童疾病治疗中采用重组人生长激素治疗法,是一种安全有效的治疗方法,胰岛素样生长因子水平提升,身高改善显著。
作者 王会丽
出处 《包头医学》 2020年第1期34-36,共3页 Journal of Baotou Medicine
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  • 1Pantel J,Machinis K,Sobrier M L,Duquesnoy P,Goossens M,Amselem S.Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution. Journal of Biological Chemistry . 2000
  • 2Park Patricia,Cohen Pinchas.The role of insulin-like growth factor I monitoring in growth hormone-treated children. Hormone Research . 2005
  • 3Pinchas Cohen,Alan D. Rogol,Campbell P. Howard,George M. Bright,Anne-Marie Kappelgaard,Ron G. Rosenfeld.??Insulin Growth Factor-Based Dosing of Growth Hormone Therapy in Children: A Randomized, Controlled Study(J)The Journal of Clinical Endocrinology & Metabolism . 2007 (7)
  • 4Alexander A. L. Jorge,Frederico G. Marchisotti,Luciana R. Montenegro,Luciani R. Carvalho,Berenice B. Mendonca,Ivo J. P. Arnhold.??Growth Hormone (GH) Pharmacogenetics: Influence of GH Receptor Exon 3 Retention or Deletion on First-Year Growth Response and Final Height in Patients with Severe GH Deficiency(J)The Journal of Clinical Endocrinology & Metabolism . 2006 (3)
  • 5Ranke Michael B,Lindberg Anders,Price David A,Darendeliler Feyza,Albertsson-Wikland Kerstin,Wilton Patrick,Reiter Edward O.Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature. Hormone Research . 2007
  • 6Biochemical markers of growth hormone (GH) sensitivity in children with idiopathic short stature: individual capacity of IGF‐I generation after high‐dose GH treatment determines the growth response to GH(J)Clinical Endocrinology . 2002 (3)
  • 7Pinchas Cohen,John Germak,Alan D. Rogol,Wayne Weng,Anne-Marie Kappelgaard,Ron G. Rosenfeld.??Variable Degree of Growth Hormone (GH) and Insulin-Like Growth Factor (IGF) Sensitivity in Children with Idiopathic Short Stature Compared with GH-Deficient Patients: Evidence from an IGF-Based Dosing Study of Short Children(J)The Journal of Clinical Endocrinology & Metabolism . 2010 (5)
  • 8P Cohen,A D. Rogol,C L. Deal,P Saenger,E O. Reiter,J L. Ross,S D. Chernausek,M O. Savage,J M. Wit.??Consensus Statement on the Diagnosis and Treatment of Children with Idiopathic Short Stature: A Summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop(J)The Journal of Clinical Endocrinology & Metabolism . 2008 (11)
  • 9Stephen F. Kemp,Joyce Kuntze,Kenneth M. Attie,Thomas Maneatis,S Butler,James Frane,Barbara Lippe.??Efficacy and Safety Results of Long-Term Growth Hormone Treatment of Idiopathic Short Stature(J)The Journal of Clinical Endocrinology & Metabolism . 2005 (9)
  • 10苏喆,杜敏联,李燕虹,马华梅,陈红珊,古玉芬.重组人生长激素治疗不同生长激素分泌状态青春前期矮小患儿追赶性生长模式分析[J].中华内分泌代谢杂志,2008,24(3):239-243. 被引量:13

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