摘要
目的:探讨不同妊娠期甲状腺功能指标参考范围,为本地区妊娠期甲状腺疾病提供可靠的诊断依据。方法:选择首次来本院进行甲状腺功能检测的不同妊娠期妇女为研究对象,分为妊娠早期(孕1~12周)、妊娠中期(孕13~27周)、妊娠晚期(孕28~40周),同期非妊娠妇女为对照组,各组220例,行促甲状腺激素(TSH)和游离甲状腺素(FT4)筛查。结果:检测中位数TSH分别为妊娠早期0.02~4.27mIU/L,妊娠中期0.08~5.07mIU/L,妊娠晚期期0.48~5.08mIU/L;FT4分别为妊娠早期12.08~24.80pmol/L,妊娠中期9.76~17.82pmol/L,妊娠晚期9.27~16.10pmol/L。与其他妊娠期及对照组比较,妊娠早期TSH水平最低,FT4最高(P<0.05)。结论:建立本地区不同妊娠期甲状腺功能指标参考值,有利于妊娠期甲状腺疾病的筛查及诊治。
Objective:To explore the reference range of thyroid function indexes of pregnant women during different gestational weeks,and to provide reliable evidence for diagnosing thyroid diseaseof women during pregnancy.Methods:The pregnant women during different gestational weeks who firstly for thyroid function testing were selected as the study objects,which included 220 women during the first trimester pregnancy(in 1-12 gestational weeks)in group A,220 women during the second trimester pregnancy(in 13-27 gestational weeks)in group B,220 women during the third trimester pregnancy(in 28-40 gestational weeks)in group C,and 220 women without pregnancy in group D.The levels of thyrotrophin(TSH)and free thyroxine(FT4)of all women were detected.Results:The median level of TSH of women in group A,B,and C were 0.02-4.27mIU/L,0.08-5.07mIU/L,and 0.48-5.08mIU/L,respectively.And the median level of FT4 of women in group A,B,and C were 12.08-24.80pmol/,9.76-17.82pmol/L,and 9.27-16.10pmol/L,respectively.Of women in group A,the TSH level was the lowest,but FT4 level was the highest(P<0.05).Conclusion:The establishment of range of thyroid function indexes of pregnant women during different gestational weeks is beneficial to the screening and diagnosis of thyroid diseases of pregnant women.
作者
万桂英
朱慧芳
陈昇
高永平
张振芳
王英娟
WAN Guiying;ZHU Huifang;CHEN Sheng;GAO Yongping;ZHANG Zhenfang;WANG Yingjuan(Yongqing County People's Hospital,Hebei Province,065600;Langfang Vocational College of Health)
出处
《中国计划生育学杂志》
2020年第1期131-133,共3页
Chinese Journal of Family Planning
基金
2016年廊坊市科学技术研究发展计划(2016013146)
