摘要
目的分析阿托伐他汀配伍盐酸小檗碱片治疗脑梗塞的临床效果。方法选取2018年1月至2019年1月收治的90例脑梗塞患者作为研究对象,按照随机数字法将其分为观察组与对照组,各45例。对照组予以阿托伐他汀钙治疗,观察组在对照组的基础上口服盐酸小檗碱片。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的血清CRP、MIF水平及Crouse积分均低于对照组(P<0.05)。两组患者均未出现肝酶异常等严重不良反应。结论阿托伐他汀配伍盐酸小檗碱片能明显改善脑梗塞患者炎症因子水平及斑块最大厚度,安全可靠,值得在临床中进一步应用。
Objective To analyze the clinical effect of atorvastatin combined with berberine hydrochloride tablets in the treatment of cerebral infarction. Methods From January 2018 to January 2019, 90 patients with cerebral infarction were selected as the study objects. According to the random number method, the patients were divided into observation group and control group, with 45 cases in each group. The control group was treated with atorvastatin calcium, and the observation group was treated with berberine hydrochloride tablets on the basis of the control group. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05). After treatment, the levels of serum CRP, MIF and Crouse score in the observation group were lower than those in the control group(P <0.05). There were no serious adverse reactions such as liver enzyme abnormality in both groups. Conclusion Atorvastatin combined with berberine hydrochloride tablets can significantly improve the levels of inflammatory factors and the maximum thickness of plaque in patients with cerebral infarction, which is safe and reliable. It is worth further application in clinic.
作者
刘昊
LIU Hao(Neurosurgery Department,Xinyang Central Hospital,Xinyang 464000,China)
出处
《临床医学研究与实践》
2020年第3期33-34,共2页
Clinical Research and Practice
关键词
脑梗塞
阿托伐他汀
盐酸小檗碱片
颈动脉斑块
cerebral infarction
atorvastatin
berberine hydrochloride tablets
carotid plaque
