摘要
目的:探讨四逆汤化裁联合安宫黄体酮治疗子宫内膜异位症的疗效及对炎性因子、内膜血供的影响。方法:选择2018年1-12月本院接诊的75例子宫内膜异位症患者,中医辩证为寒凝血瘀证,通过随机数表法分为观察组(40例)和对照组(35例),均予安宫黄体酮治疗,观察组加用四逆汤化裁方剂,两组均以4周为1个疗程,连续治疗3个疗程。比较两组临床疗效、中医症候积分、血清肿瘤坏死因子-α(TNF-α)、白介素(IL-6、IL-8)、子宫动脉搏动指数(PI)、阻力指数(RI)及不良反应。结果:观察组临床总有效率(92.5%)高于对照组(74.3%)(P<0.05),中医症候积分(4.3±0.4)分、血清TNF-α(61.0±7.2)ng/L、IL-6(35.4±3.8)ng/L、IL-8(82.3±9.4)ng/L、子宫动脉PI(1.0±0.2)、RI(0.4±0.1)均低于对照组[(6.2±0.6)分、(78.54±9.3)ng/L、(47.0±4.6)ng/L、(103.4±10.7)ng/L、(1.33±0.2)、(0.6±0.1)](P<0.05);两组不良反应总发生率(8.6%、5.0%)无差异(P>0.05)。结论:四逆汤化裁联合安宫黄体酮治疗寒凝血瘀证子宫内膜异位症的疗效显著,可有效改善炎症状态、内膜血供,促进疾病恢复。
Objective:To explore the curative efficacy of Sini decoction huacai combined with medroxyprogesterone acetate for treating women with endometriosis,and to study its effect on inflammatory factors and intimal blood supply of women.Methods:75 women with endometriosis who had been diagnosed to cold coagulation and blood stasis syndrome by TCM Dialectics were selected and were divided into the study group(40 women treated with medroxyprogesterone acetate combined with Sini decoction huacai for 12 weeks)and control group(35 women treated with medroxyprogesterone acetate for 12 weeks)from January 2018 to December 2018.The clinical efficacy,TCM symptom score,serum inflammatory factors,such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and IL-8,and endometrial receptivity,such as uterine artery pulsation index(PI)and resistance index(RI),and adverse reaction rate of women were compared between the two groups.Results:After treatment,the total effective rate of women in the study group was 92.5%,which was significant higher than that(74.3%)of women in the control group(P<0.05).The TCM symptom score,the levels of serum TNF-,IL-6 and IL-8,the values of uterine artery PI and RI of women in the study group were 4.3±0.4 scores,61.0±7.2ng/L,35.4±3.8 ng/L,82.3±9.4ng/L,and 1.0±0.2 and 0.4±0.1,respectively,which were significant lower than those(6.2±0.6 scores,78.54±9.3ng/L,47.0±4.6ng/L,103.4±10.7ng/L,and 1.33±0.2,and 0.6±0.1,respectively)of women in the control group(P<0.05).The total incidence of adverse reactions of women in the study group was 8.6%,which had no significant different to that(5.0%)of women in the control group(P>0.05).Conclusion:Sini decoction huacai combined with medroxyprogesterone acetate for treating women with endometriosis because of cold coagulation and blood stasis syndrome has good efficacy,which can effectively improve inflammation situation of women,can increase their intimal blood supply,and can promote the recovery of disease.
作者
潘惠兰
史佳
戴海青
PAN Huilan;SHI Jia;DAI Haiqing(Hainan Traditional Chinese Medicine Hospital,Hainan Province,572000;Hainan People's Hospital)
出处
《中国计划生育学杂志》
2020年第2期168-171,共4页
Chinese Journal of Family Planning
关键词
子宫内膜异位症
安宫黄体酮
四逆汤化裁
炎症状态
内膜血供
寒凝血瘀证
Endometriosis
Medroxyprogesterone acetate
Sini Decoction Huacai
Inflammatory state
Intimal blood supply
Cold coagulation and blood stasis syndrome
