摘要
目的观察程序性死亡蛋白-配体1(PD-L1)检测为阴性的食管癌患者长周期应用Opdivo治疗的效果及其相关不良反应的护理。方法对1例仅单独应用纳武单抗Opdivo长达40周期且PD-L1检测为阴性的晚期异时性食管癌老年患者,从用药管理、心理疏导、不良反应的观察等方面,制订详细的个体化护理措施。结果患者在用药期间生命体征平稳,KPS评分由60分提高至80分,癌胚抗原测定由15.36μg/L降至9.45μg/L,免疫性皮炎、甲状腺功能减退等不良反应均已缓解。结论得到了患者长周期应用Opdivo治疗的护理经验,同时为临床应用纳武单抗治疗肿瘤提供相应的询证护理证据支持。
Objective To observe the effect of long cycle application of Opdivo in patients with esophageal cancer whose programmed death ligand 1(PD-L1)test was negative and the nursing care of its related adverse reactions.Methods For an elderly patient with advanced heterochronous esophageal cancer with only 40 cycles of Opdivo and negative PD-L1,detailed individualized nursing measures were made from the aspects of medication management,psychological guidance and observation of adverse reactions.Results The vital signs of the patients were stable,the KPS score was increased from 60 to 80,the carcinoembryonic antigen was reduced from 15.36μg/L to 9.45μg/L,and the adverse reactions such as immune dermatitis and hypothyroidism were relieved.Conclusions The nursing experience of patients treated with Opdivo for a long period has been obtained,and the corresponding nursing evidence support has been provided for the clinical application of navumab in the treatment of tumor.
作者
匡红
石海燕
廖亮
Kuang Hong;Shi Haiyan;Liao Liang(Department of Gastroenterology Ward,the Second Clinical Center,PLA General Hospital,Clinical Center of Government Geriatrics Diseases,Beijing 100048,China)
出处
《中国实用护理杂志》
2020年第7期550-552,共3页
Chinese Journal of Practical Nursing
关键词
食管鳞癌
程序性死亡蛋白-1
单一用药
纳武单抗
Squamous cell carcinoma of esophagus
Programmed death ligand 1
Monotherapy
Opdivo
