摘要
目的探讨动脉硬化性血栓性脑梗塞(ATCI)患者血清前蛋白转化酶枯草溶菌素9(PCSK9)和低密度脂蛋白胆固醇(LDL-C)水平的变化及意义。方法选取2017年1月-2018年6月本院收治的86例ATCI患者(观察组)和同期体检的86例健康志愿者(对照组)。比较2组患者的血清PCSK9和LDL-C水平,并分析ATCI患者脑梗塞面积及病情严重程度与血清PCSK9和LDL-C水平的关系。结果观察组血清PCSK9和LDL-C水平均显著高于对照组,差异有统计学意义(P<0.05)。不同脑梗塞面积和病情严重程度的ATCI患者血清PCSK9和LDL-C水平之间比较,差异均有统计学意义(P<0.05),且随着脑梗塞面积和病情严重程度的增大而加重,血清PCSK9和LDL-C水平均升高(P<0.05)。Pearson相关性分析显示,脑梗塞面积及病情严重程度与血清PCSK9和LDL-C水平均呈正相关(r值分别为0.624和0.593及0.613和0.582;P<0.05)。结论高水平的血清PCSK9和LDL-C与ATCI的发生相关,且血清PCSK9和LDL-C水平均与脑梗塞面积及病情严重程度呈正相关,可作为ATCI的预后评估指标和治疗靶点。
Objective To investigate the changes and significance of serum proprotein-converting enzyme,bacteriolysin 9(PCSK9)and low density lipoprotein cholesterol(LDL-C)levels in patients with atherosclerotic thrombotic cerebral infarction(ATCI).Methods From January 2017 to June 2018,86 patients with ATCI(observation group)and 86 healthy volunteers(control group)were selected.The serum levels of PCSK9 and LDL-C were compared between the two groups,and the relationship between cerebral infarction area and the severity of cerebral infarction,the serum levels of PCSK9 and LDL-C was analyzed.Results The levels of serum PCSK9 and LDL-C in the observation group were significantly higher than those in the control group,with the differences statistically significant(P<0.05).The differences in the levels of serum PCSK9 and LDL-C among the ATCI patients with different cerebral infarct size and severity were statistically significant(P<0.05).With the increase of cerebral infarction area and severity,the levels of serum PCSK9 and LDL-C increased(P<0.05).Pearson correlation analysis showed that the area and severity of cerebral infarction were positively correlated with levels of serum PCSK9 and LDL-C(r=0.624,r=0.593;r=0.613,r=0.582;P<0.05).Conclusion High levels of serum PCSK9 and LDL-C are associated with the occurrence of ATCI,and the levels of serum PCSK9 and LDL-C are positively correlated with the size of cerebral infarction and the severity of the disease,which can be used as prognostic indicators and therapeutic targets of ATCI.
作者
吴金隆
杨堃
柳侠平
刘晓霞
WU Jin-long;YANG Kun;LIU Xia-ping;LIU Xiao-xia(Rehabilitation Department,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou,Zhejiang 325000,China;不详)
出处
《中国卫生检验杂志》
CAS
2020年第1期58-60,共3页
Chinese Journal of Health Laboratory Technology
