摘要
目的随着医疗技术的发展与普及,腹腔镜技术也逐渐成熟,被临床广泛应用,并取得了显著治疗效果。本研究分析腹腔镜手术治疗对良性卵巢肿瘤患者卵巢功能及内分泌的影响。方法选择2018-02-01-2019-03-01南阳市第一人民医院收治的良性卵巢囊肿患者为研究对象,根据年龄和病情等因素选择观察组与对照组,各39例。对照组采用开腹手术,观察组采用腹腔镜手术。比较两组患者卵巢功能、内分泌、围术期各指标、术后月经及妊娠情况。结果术后6个月,观察组卵泡刺激素(follicle-stimulating hormone,FSH)为(17.82±1.65)mu/mL,低于对照组的(20.45±3.04)mu/mL,t=4.748,P<0.001;黄体生成素(luteinizing hormone,LH)为(16.32±2.45)mu/mL,低于对照组的(18.45±3.34)mu/mL,t=3.211,P=0.002;雌二醇(estradiol,E2)含量为(33.58±2.68)pg/mL,高于对照组的(31.41±2.56)pg/mL,t=3.657,P=0.001。术后2d,观察组胰高血糖素、皮质醇(cortisol,COR)、β-内啡肽和促甲状腺激素(thyroid stimulating hormone,TSH)含量分别为(348.52±54.45)pg/mL、(154.58±16.34)nmol/L、(165.45±40.80)pg/mL和(1.11±0.21)μg/L,低于对照组的(379.58±71.23)pg/mL、(172.25±16.85)nmol/L、(185.38±42.70)pg/mL和(172.25±16.85)μg/L,差异有统计学意义,均P<0.05。观察组患者术中出血量、手术时间及术后排气时间分别为(33.34±7.23)mL、(40.25±11.65)min和(21.74±1.51)h,低于对照组的(70.25±8.75)mL、(50.58±12.42)min和(25.40±3.62)h,差异有统计学意义,均P<0.001。观察组月经异常率为2.56%,低于对照组的20.15%,χ^2=4.522,P=0.013;观察组术后成功妊娠率为93.33%,高于对照组的42.86%,χ^2=10.359,P=0.001。结论良性卵巢肿瘤患者采用腹腔镜手术,可有效缩短患者手术时间及术后恢复时间,减少术中出血量,对患者卵巢功能及内分泌影响较小。
OBJECTIVE With the development and popularization of medical technology,laparoscopic technology has gradually matured,and has been widely used in clinic,and achieved remarkable therapeutic effect.This study aims to analyze the effect of laparoscopic surgery on ovarian function and endocrine in patients with benign ovarian tumor.METHODS The patients with benign ovarian cyst who treated in the hospital from February 1,2018 to March 1,2019 were selected as subjects.All selected cases were divided into observation group and control group according to the age and conditions of disease,with 39 cases in each group.Control group underwent open surgery,and observation group underwent laparoscopic surgery.The ovarian function,endocrine,perioperative indexes,postoperative menstruation and pregnancy were compared between two groups.RESULTS After surgery for 6 months,the FSH and LH in observation group[(17.82±1.65)mu/ml,(16.32±2.45)mu/ml]were lower than those in control group[(20.45±3.04)mu/ml,(18.45±3.34)mu/ml],while the content of E2 in observation group[(33.58±2.68)pg/ml]was higher than that in control group[(31.41±2.56)pg/ml],and the difference was statistically significant(t=4.748,3.211,3.657,P<0.001,0.002,0.001).After surgery for 2 d,the glucagon,COR,β-endorphin,TSH contents in observation group[(348.52±54.45)pg/ml,(154.58±16.34)nmol/L,(165.45±40.80)pg/mL,(1.11±0.21)μg/L]were lower than those in control group[(379.58±71.23)pg/ml,(172.25±16.85)nmol/L,(185.38±42.70)pg/ml,(172.25±16.85)μg/L],and the difference was statistically significant(all P<0.05).The intraoperative bleeding volume,operation time and postoperative exhaust time in observation group[(33.34±7.23)ml,(40.25±11.65)min,(21.74±1.51)h]were lower than those in control group[(70.25±8.75)ml,(50.58±12.42)min,(25.40±3.62)h],and the difference was statistically significant(all P<0.001).Compared with control group,the abnormal rate of menstruation in observation group was 2.56%,lower than that of the control group,and the difference was statistically significant(χ^2=4.522,P=0.013);The success rate of postoperative pregnancy in observation group was higher than that in control group(93.33%vs 42.86%),and the difference was statistically significant(χ^2=10.359,P=0.001).CONCLUSION Laparoscopic surgery for patients with benign ovarian tumor has less effect on ovarian function and endocrine function,it can shorten operation time and postoperative recovery time,reduce intraoperative bleeding volume,and have less impact on ovarian function of patients,which is worthy of promotion in the patients with fertility requirements.
作者
谢旭
赵晓芳
XIE Xu;ZHAO Xiao-fang(Department of Gynecology,Nanyang First Peoples Hospital,Nanyang 473000,P.R.China)
出处
《社区医学杂志》
2019年第22期1433-1436,共4页
Journal Of Community Medicine
关键词
良性卵巢肿瘤
腹腔镜手术
卵巢功能
benign ovarian tumor
laparoscopic surgery
ovarian function
