摘要
细胞自噬是细胞在应激条件下降解胞内受损成分的过程,涉及多信号分子参与。在疾病发生、发展过程中,细胞自噬既可抑制或延缓疾病发展,还可使病情恶化,故寻找在不同阶段调控细胞自噬作用的因子探究其有效作用靶点具有重要意义。非编码RNA(noncoding RNA,ncRNA)是从基因组中转录出来的不行使编码蛋白质作用的一类RNA的总称。进几年来,越来越多不同ncRNA被发现,并在动物机体生理和病理过程中发挥着重要的调控作用。已有研究表明,ncRNA在细胞自噬发生过程起到重要的调控作用。从微小RNA(MicroRNA,miRNA)、长链非编码RNA(Long noncoding RNAs,lncRNA)、环状RNA(CircularRNA,circRNA)几方面综述了ncRNA在细胞自噬通路中的调节作用,为癌症等疾病治疗以及分子标记提供理论指导和新思路。
Autophagy is a process in which cells degrade intracellular damaged components under stress conditions and involves the involvement of multiple signaling molecules. In the process of disease occurrence and development,autophagy can inhibit or delay the development of the disease,and can also make the disease worse. Therefore,it is of great significance to find the factors that regulate the autophagy at different stages to explore its effective target. Noncoding RNA( ncRNA) is a generic term for a class of RNA that is transcribed from the genome and does not travel to encode proteins. Over the years,more and more different ncRNAs have been discovered and play an important regulatory role in the physiological and pathological processes of animals. Studies have shown that ncRNA plays an important regulatory role in the process of autophagy. This article intends to review the regulation of ncRNA in the autophagy pathway from microRNAs( miRNAs),long noncoding RNAs( lncRNAs),circular RNAs( circRNAs),and to treat diseases such as cancer and Molecular markers provide theoretical guidance and new ideas.
作者
沈冰蕾
王宇轩
韩硕
李熹
杨卓妮娜
邹紫雯
刘娟
SHEN Bing-lei;WANG Yu-xuan;HAN Shuo;LI Xi;YANG Zhuo-ni-na;ZOU Zi-wen;LIU Juan(College of Animal Science,Heilongjiang Bayi Agricultural University,Daqing 163319,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2019年第12期56-63,共8页
China Biotechnology
基金
中国博士后科学基金(2018M631970)
黑龙江省博士后启动基金(LBH-Z16166)
黑龙江省牛病防制重点实验室开放课题(PCBD201708)资助项目
