摘要
目的探讨孕期梅毒疗法对新生儿血清检测结果及妊娠结局的影响。方法选取2014年4月至2016年1月在湖州市妇幼保健院产科孕早期就接受孕期梅毒疗法的梅毒感染孕产妇47例作为治疗组,随机选取同期在我院分娩而未接受治疗的梅毒感染产妇47例作为对照组,比较分析两组孕产妇妊娠结局和新生儿结局以及新生儿血清检测结果的变化情况。结果治疗组孕产妇中早产、流产、死胎等的不良妊娠结局的发生率均低于对照组,差异有统计学意义(χ^2值分别为4.45、5.97、3.90、23.70,均P<0.05);治疗组新生儿出现低体重儿、先天梅毒、窒息、死亡等不良结局的发生率均低于对照组(χ^2值分别为5.20、14.05、3.89、4.79,均P<0.05);两组新生儿血清快速血浆反应快速血浆反应素试验(RPR)滴度有统计学差异(χ^2=4.39,P=0.04);不同疗程孕期梅毒疗法新生儿的血清RPR滴度之间有统计学差异(χ^2=7.45,P=0.04)。结论孕期梅毒疗法能够有效控制新生儿血清RPR效价,降低先天性梅毒发生风险,改善梅毒感染孕妇的妊娠结局和新生儿结局。
Objective To explore the effect of syphilis therapy in pregnancy on the results of neonatal serum test and pregnancy outcome.Methods From April 2014 to January 2016,47 pregnant women with syphilis infection who received syphilis treatment in the first trimester in Huzhou Maternal and Child Health Care Hospital were selected as the treatment group,and the 47 pregnant women with syphilis infection who gave birth in our hospital at the same time but did not receive treatment were randomly selected as the control group.We compared and analyzed the pregnancy outcome and newborn outcome in the two groups.Results The incidence of adverse pregnancy outcomes in the treatment group was lower than that in the control group(χ^2=4.45,5.97,3.90,23.70,P<0.05 for all);The incidence of low birth weight,congenital syphilis,asphyxia,death and other adverse outcomes in the treatment group was lower than that in the control group(χ^2=5.20,14.05,3.89,4.79,P<0.05 for all);There was a significant difference in the titer of RPR between the two groups(χ^2=4.39,P=0.04);There was a significant difference in RPR titer among the newborns treated with different courses of syphilis during pregnancy(χ^2=7.45,P=0.04).Conclusion Syphilis therapy during pregnancy can effectively control the RPR titer of newborn serum,reduce the risk of congenital syphilis,and improve the pregnancy outcome and newborn outcome of pregnant women with syphilis infection.
作者
张平
向春芳
ZHANG Ping;XIANG Chunfang(Department of Obstetrics,Huzhou Maternal and Child Health Hospital,Zhejiang Huzhou 313000,China)
出处
《中国妇幼健康研究》
2019年第12期1495-1498,共4页
Chinese Journal of Woman and Child Health Research
关键词
孕期梅毒疗法
新生儿
血清检测
妊娠结局
pregnancy syphilis therapy
neonatal
serum test
pregnancy outcome
