摘要
慢性滑膜炎是一种非特异性滑膜增生性疾病,通常会侵袭软骨,对软骨造成损害,并影响关节功能。各种关节炎均会引起滑膜炎性病变,且慢性滑膜炎在类风湿性关节炎、骨关节炎等疾病中最为多见。类风湿性滑膜炎与骨关节炎性滑膜炎的发病机制有着明显差别。以滑膜细胞的作用为中心对慢性滑膜炎的发病机制进行探讨,并对目前慢性滑膜炎药物治疗的研究进展进行综述,为滑膜炎的作用机制研究及抗滑膜炎新药研发提供参考。
Chronic synovitis is a non-specific proliferative lesion of synovium which usually invades and causes damage to cartilage and eventually affects the function of joint.Various types of arthritis can cause synovial inflammation which is commonly observed in rheumatoid arthritis and osteoarthritis.However,the pathogenesis of rheumatoid synovitis is significantly different from that of osteoarthritis synovitis.In this article,the research advances in the pathogenesis of chronic synovitis was discussed with a focus on the role played by synoviocytes and the current research progress of pharmacotherapy for chronic synovitis was reviewed,so as to provide reference for the study of synovitis pathogenesis and the development of new anti-synovitis drugs.
作者
李亚楠
刘吉华
余伯阳
LI Yanan;LIU Jihua;YU Boyang(Jiangsu Key Laboratory of TCM Evaluation and Translational Research,China Pharmaceutical University,Nanjing 211198,China)
出处
《药学进展》
CAS
2019年第11期856-864,共9页
Progress in Pharmaceutical Sciences
基金
国家重大新药创制科技重大专项（No.2017ZX09101002-002-003）
