摘要
目的探究曲伏前列素滴眼液在原发性开角型青光眼(primary open angle glaucoma,POAG)临床治疗的疗效。方法选取2017年6月至2019年6月本院收治的POAG患者84例,采用随机数字表分为观察组与对照组,各42例。给予观察组患者曲伏前列素滴眼液治疗8周,给予对照组患者马来酸噻吗洛尔滴眼液治疗8周,比较两组治疗前后眼压、治疗总有效率与不良反应发生率。结果治疗前,两组患者的眼压比较,差异无统计学意义;治疗4周、8周后,观察组患者的眼压低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的治疗总有效率(95.24%)高于对照组(73.81%),差异有统计学意义(P<0.05)。两组患者的色素沉着发生率、结膜充血发生率比较,差异无统计学意义;观察组睫毛增粗增长发生率(16.67%)低于对照组(0.00%),差异有统计学意义(P<0.05);观察组患者的心动过缓发生率(0.00%)低于对照组(14.29%),差异有统计学意义(P<0.05)。结论曲伏前列素滴眼液治疗POAG的短期疗效优于马来酸噻吗洛尔滴眼液,其降低眼压效果显著,安全性高,值得推广。
Objective To investigate the therapeutic effect of travoprostol eye drops on primary open-angle glaucoma(primary open angle glau coma,POAG).Methods From June 2017 to June 2019,84 patients with poag were selected and divided into 42 patients in the observation group and 42 in the control group by random digital table.The patients in the observation group were treated with trovoprostol eye drops for 8 weeks,and the pa tients in the control group were treated with timololol maleate eye drops for 8 weeks.Results Before treatment,there was no significant difference in intraocular pressure between the two groups.After 4 weeks and 8 weeks of treatment,the intraocular pressure of the patients in the observation group was lower than that in the control group(P<0.05),the difference was statistically significant.After treatment,the total effective rate of the patients in the observation group(95.24%)was higher than that in the control group(73.81%),the difference was statistically significant(P<0.05).The inci dence of pigmentation and conjunctival congestion in the two groups;The incidence of eyelash thickening in the observation group(16.67%)was low er than that in the control group(0.00%).The incidence of bradycardia in the observation group(0.00%)was lower than that in the control group(14.29%),and the difference was statistically significant(P<0.05).Conclusion The short-term efficacy of trivoprost eye drops in the treatment of POAG is better than that of timolol Maleate eye drops.It is effective in reducing intraocular pressure and is safe,so it is worth popularizing.
作者
王美华
贾娟
徐丽
Wang Meihua;Jia Juan;Xu Li(Department of Ophthalmology,Shenyang Fourth People's Hospital,Shenyang,Liaoning,110031,China)
出处
《当代医学》
2020年第7期117-119,共3页
Contemporary Medicine
