摘要
幽门螺杆菌(Hp)不仅与消化性溃疡、胃癌等胃部疾病发生相关,还与冠心病、牙周炎、缺铁性贫血、特发性血小板减少性紫癜、慢性荨麻疹等其他系统疾病的发病相关,Hp感染已成为世界性公共卫生问题。根除Hp利大于弊,因此根除Hp感染成为全球关注的热点。随着抗生素耐药发生率的不断升高,Hp根除治疗药物及方案亦处于不断更新中,但目前首次根除Hp治疗的成功率仍较低。随着治疗方案个体化的进展,对不同国家和地区抗生素耐药机制以及根除Hp药物作用机制、耐药机制和不良反应的研究显得十分重要。
Helicobacter pylori(Hp) is not only related to peptic ulcer,gastric cancer and other gastric diseases,but also to coronary heart disease,periodontitis,iron deficiency anemia,idiopathic thrombocytopenic purpura,chronic urticaria and other systemic diseases.Hp infection has become a worldwide public health problem.Eradicating Hp has more advantages than disadvantages,so it has become a global hotspot.With the increasing of incidence of antibiotic resistance,Hp eradication drugs and programs are also in constant updating,but the first-time success rate of Hp eradication is still low.With the development of individualized treatment,it is very important to study the mechanism of antibiotic resistance,the mechanism of Hp eradication,the mechanism of drug resistance and adverse reactions in different countries and regions.
作者
张俊璇
方超然
时鑫鑫
谭浩雨
郝欣
李建辉
ZHANG Junxuan;FANG Chaoran;SHI Xinxin;TAN Haoyu;HAO Xin;LI Jianhui(Chengde Medical College,Chengde 067000,China;Department of Surgery,Beijing Water Resources Hospital,Beijing 100089,China;Department of Gastroenterology,Chengde Central Hospital,Chengde 067000,China)
出处
《医学综述》
2020年第2期316-321,共6页
Medical Recapitulate
关键词
幽门螺杆菌
根除治疗
质子泵抑制剂
抗生素
铋剂
益生菌
中药
Helicobacter pylori
Eradication therapy
Proton pump inhibitors
Antibiotics
Bismuth
Probiotics
Traditional Chinese medicine
