摘要
急性缺血性脑卒中发生后核心梗死区周围仍存在保留了细胞代谢的缺血半暗带,提高血氧浓度可一定程度改善缺血缺氧脑组织的细胞代谢能力。氧治疗可分为常规低流量吸氧治疗和非常规氧治疗,后者又分为常压高氧治疗和高压氧治疗。目前,针对脑卒中本身病变所致呼吸系统受损或相关肺部并发症的氧治疗疗效确切,最新的大样本临床试验证实予以无缺氧指征的脑卒中患者预防性低流量吸氧并不能改善预后;而动物实验及临床试验均不同程度证实了常压高氧和高压氧疗法在急性缺血性脑卒中早期(6 h内)及短期治疗的疗效。常压高氧及高压氧疗法各自及分别与静脉溶栓等药物联用是当前热点研究方向。
There is an ischemic penumbra with cell metabolism preserved around the core infarct area after acute ischemic stroke.Increasing blood oxygen concentration can improve the cellular metabolism of ischemic and hypoxic brain tissue.Oxygen therapy can be divided into conventional low flow oxygen therapy and unconventional oxygen therapy,and the latter can be divided into normobaric oxygen treatment and hyperbaric oxygen treatment.At present,the effect of oxygen therapy for respiratory system damage or related pulmonary complications caused by stroke is definite.Recent large-sample clinical trials have confirmed that prophylactic low-flow oxygen inhalation for stroke patients with no indication of hypoxia cannot improve prognosis,while animal and clinical trials have also confirmed the efficacy of normobaric oxygen and hyperbaric oxygen therapy in the short-term(within 6 hours) and early treatment of acute ischemic stroke.normobaric oxygen and hyperbaric oxygen therapy used alone or in combination with intravenous thrombolysis drugs are also current hotspot in the research field.
作者
李知静
金香兰
LI Zhijing;JIN Xianglan(Department of Neurology,China Medical University 202 Hospital,Shenyang 110000,China)
出处
《医学综述》
2020年第2期306-310,共5页
Medical Recapitulate
基金
辽宁省第一批科学技术计划(2011225021)
关键词
急性缺血性脑卒中
脑梗死
缺氧
低流量吸氧
夜间吸氧
高压氧
常压高氧
Acute ischemic stroke
Cerebral infarction
Hypoxia
Low flow oxygen
Nocturnal oxygen inhalation
Hyperbaric oxygen
Normobaric oxygen
