摘要
目的建立重庆地区表观健康人群血清睾酮的参考区间。方法选取体检健康成年人为研究对象,按性别、年龄分组,检测血清睾酮水平,根据美国临床和实验室标准协会C28-A3文件相关要求,建立血清睾酮的95%参考区间。结果研究纳入体检健康人群共602例,其中男性300例,血清睾酮水平呈正态分布,平均水平为(4.89±1.33)ng/mL;女性302例,血清睾酮水平呈非正态分布,水平中位数(四分位数)为[0.38(0.20~0.57)]ng/mL,二者比较差异有统计学意义(P<0.05)。进一步年龄分组比较血清睾酮测定结果,男性血清睾酮水平在两个年龄亚组间的差异无统计学意义(P>0.05),女性的睾酮水平随年龄增长而降低,20~<50岁年龄组明显高于≥50岁年龄组(P<0.05)。重庆地区表观健康人群血清睾酮的参考区间:男性为2.28~7.50 ng/mL,女性20~<50岁为0.10~1.03 ng/mL,女性≥50岁为0.10~0.70 ng/mL。结论初步建立了重庆地区表观健康人群不同性别的血清睾酮的参考区间,女性人群需根据年龄分组采用不同的参考区间。
Objective To establish a reference interval for serum testosterone in apparently healthy people in Chongqing.Methods The healthy adults were selected as the research objects.The serum testosterone concentration was measured according to the sex and age groups.The 95%reference range of serum testosterone was established according to the relevant requirements of C28-A3 document of American Association of clinical and laboratory standards.Results There were 602 healthy people included in the study,300 of them were male,the serum testosterone concentration was normal distribution,the average concentration was(4.89±1.33)ng/mL;302 of them were female,the serum testosterone concentration was abnormal distribution,the median concentration(quartile)was[0.38(0.20-0.57)]ng/mL,the difference was statistically significant(P<0.05).There was no significant difference between the two age subgroups in the serum testosterone concentration of men(P>0.05).The serum testosterone concentration of women decreased with the increase of age.The serum testosterone concentration of 20 to 50 years old age group was significantly higher than that of≥50 years old age group(P<0.05).The reference range of serum testosterone in the apparent healthy population in Chongqing:2.28-7.50 ng/mL for men,0.10-1.03 ng/mL for women aged 20 to 50 years old,and 0.10-0.70 ng/mL for women aged≥50 years old.Conclusion The reference interval of serum testosterone of different genders in the apparent healthy population in Chongqing area is preliminarily established,and different reference intervals should be adopted for the female population according to the age group.
作者
田思思
罗杰
廖玲
雷国勤
巫志宇
TIAN Sisi;LUO Jie;LIAO Ling;LEI Guoqin;WU Zhiyu(Department of Clinical Laboratory,Daping Hospital of Army Medical University,Chongqing 400042,China;Department of Laboratory Pathology,954th Hospital of the PLA Army,Lasa,Xizang 856000,China)
出处
《国际检验医学杂志》
CAS
2020年第3期346-349,354,共5页
International Journal of Laboratory Medicine
关键词
睾酮
表观健康
参考区间
testosterone
apparent health
reference interval
