摘要
目的探讨依诺肝素联合替格瑞洛治疗急性冠状动脉综合征的疗效,及其与血清脑利钠肽(BNP)和血清肌钙蛋白Ⅰ(cTnI)的相关性。方法选择医院2016年1月至2018年1月收治的急性冠状动脉综合征患者150例,按随机数字表法分为A组、B组和C组,各50例。A组患者给予依诺肝素治疗,B组患者给予替格瑞洛治疗,C组患者给予依诺肝素联合替格瑞洛治疗。3组患者均连续治疗2周。结果总有效率A组为68. 00%,B组为74. 00%,C组为92. 00%,3组间差异有统计学意义(P <0. 05);治疗后,C组患者左室射血分数(LVEF)高于A组和B组患者,SYNTAX评分低于A组和B组患者,3组间差异有统计学意义(P <0. 05);治疗后,C组患者血清BNP和cTnI水平均显著低于A组和B组,3组间差异有统计学意义(P <0. 05);经Pearson相关性检验分析,BNP和cTnI与LVEF呈负相关,与SYNTAX评分呈正相关(P <0. 05);A组、B组、C组患者治疗期间不良反应发生率分别为8. 00%,10. 00%,16. 00%,3组间差异无统计学意义(P> 0. 05)。结论与单独用药相比,依诺肝素联合替格瑞洛治疗急性冠状动脉综合征疗效更好,患者的心功能、SYNTAX评分、血清学指标等均有显著改善,且疗效指标与BNP和cTnI水平呈显著相关性。
Objective To investigate the application of enoxaparin combined with tegrilol in the treatment of acute coronary syndrome and the correlation between serum brain natriuretic peptide( BNP) and serum troponin Ⅰ( cTnI). Methods A total of 150 patients with acute coronary syndrome who were treated in the hospital from January 2016 to January 2018 were selected and divided into groups A,B and C according to the random number table methods,50 cases in each group. Group A received enoxaparin,group B received tegrilol,and group C received enoxaparin combined with tegrilol. All patients were treated for 2 consecutive weeks. Results The total effective rate of group A was 68. 00%,74. 00% in group B and 92. 00% in group C. There was significant difference among the three groups( P < 0. 05). After treatment,the left ventricular ejection fraction( LVEF) of group C was higher than that of the other two groups,and the SYNTAX score was lower than that of the other two groups. There was significant difference among the three groups( P < 0. 05);the serum BNP and c TnI levels in group C were significantly lower than those in the other two groups,and there was significant difference among the three groups( P < 0. 05);Pearson correlation test showed that BNP and c TnI were negatively correlated with LVEF and positively correlated with SYNTAX score( P < 0. 05). The incidence of adverse reactions during treatment was 8. 00%,10. 00% and 16. 00%,respectively,with no significant difference between the three groups( P > 0. 05). Conclusion Compared with the single drug,enoxaparin combined with tegrilol is more effective in the treatment of acute coronary syndrome. The cardiac function,SYNTAX score and serological indexes of patients have been significantly improved,and there is a significant correlation between the therapeutic indexes of patients and the levels of BNP and cTnI.
作者
李文芳
翟明霞
LI Wenfang;ZHAI Mingxia(Jingxing County Hospital,Shijiazhuang,Hebei,China 050300)
出处
《中国药业》
CAS
2020年第3期81-83,共3页
China Pharmaceuticals
基金
2018年度河北省医学科学研究重点课题计划[20181136]
