摘要
目的探究磷酸奥司他韦胶囊对急诊呼吸道病毒性感染者抗病毒的临床疗效,并分析其安全性。方法方便选择该院自2017年8月—2018年8月期间收治的急诊呼吸道病毒性感染患者300例,利用随奇偶数分组法将其分成参照组与治疗组,参照组给予患者利巴韦林注射液和维C银翘片,治疗组给予患者磷酸奥司他韦,观察并对比两组患者临床治疗效果,临床观察指标、炎性因子水平以及不良反应发生率的情况。结果治疗组患者临床治疗总有效率为94.5%,参照组患者临床治疗总有效率为82.0%,差异有统计学意义(χ^2=11.680,P<0.05)。治疗组患者在退热时间(24.57±2.09)h、临床症状改善时间(28.38±4.29)h、痊愈时间(51.43±3.01)h、TNF-α(1.22±0.31)pg/mL、IL-6(1.37±0.21)pg/mL、hs-CRP(10.41±3.04)μg/L方面数据,均明显优于参照组,差异有统计学意义(t=64.950、30.370、45.410、10.500、8.600、8.200,P<0.05);同时治疗组患者不良反应发生率为10.0%与参照组(13.3%)相比较,差异无统计学意义(χ^2=0.810,P>0.05)。结论应用磷酸奥司他韦胶囊对急诊呼吸道病毒性感染患者进行抗病毒治疗,能够明显改善患者临床症状和炎性因子水平,降低不良反应的发生率,有利于提高临床治疗效果,值得研究推广。
Objective To investigate the clinical efficacy of oseltamivir capsules in the treatment of viral infection in emergency respiratory tract infections,and to analyze its safety.Methods A total of 300 patients with acute respiratory viral infections admitted to the hospital from August 2017 to August 2018 were conveniently selected.The patients were divided into a reference group and a treatment group by the odd-even group method.The reference group was given ribavirin injection and Vitamin C yinqiao tablet,the treatment group was given oseltamivir phosphate,observe and compare the clinical treatment effect,clinical observation indicators,inflammatory factor levels and the incidence of adverse reactions.Results The total effective rate of clinical treatment was 94.5%in the treatment group and 82.0%in the reference group.The difference was statistically significant(χ^2=11.680,P<0.05).The treatment group had antipyretic time(24.57±2.09)h,clinical symptom improvement time(28.38±4.29)h,recovery time(51.43±3.01)h,TNF-α(1.22±0.31)pg/mL,IL-6(1.37±0.21)pg/mL,hs-CRP(10.41±3.04)μg/L data were significantly better than the reference group,the difference was statistics significance(t=64.950,30.370,45.410,10.500,8.600,8.200,P<0.05);at the same time,the incidence of adverse reactions in the treatment group was 10.0%compared with the reference group(13.3%),which was not statistically significant(χ^2=0.810,P>0.05).Conclusion The application of oseltamivir capsules in the treatment of patients with emergency respiratory viral infection can significantly improve the clinical symptoms and inflammatory factors,reduce the incidence of adverse reactions,and improve the clinical treatment effect.It is worthy of research and promotion.
作者
雷霆
陈亮
赵文姣
LEI Ting;CHEN Liang;ZHAO Wen-jiao(Department of Emergency,Fuzhou Second Hospital Affiliated to Xiamen University,Fuzhou,Fujian Province,350007 China)
出处
《中外医疗》
2019年第35期88-90,共3页
China & Foreign Medical Treatment
关键词
磷酸奥司他韦
利巴韦林
急诊
呼吸道病毒性感染
抗感染
Oseltamivir phosphate
Ribavirin
Emergency
Respiratory viral infection
Anti-infection
Efficacy
