摘要
目的: 探讨盐酸纳美芬联合鼠神经生长因子(mNGF)对新生儿缺血缺氧性脑病(HIE)的效果,并分析对其脑电图背景活动、预后的影响。 方法: 选取104例新生儿HIE作为受试者,按简单随机化方法分为常规组和联合组,常规组均给予基础支持+mNGF,联合组均给予基础支持+mNGF+盐酸纳美芬。对比治疗前后脑电图背景活动变化,临床疗效,药物不良反应及后遗症。 结果: 两组基线资料对比均无统计学差异(P>0.05);治疗后两组电静息、爆发-抑制、低电压、弥漫性 波、单一节律放电发生率均显著降低(P<0.05),且治疗后联合组上述脑电异常活动发生率均明显低于常规组(P<0.05);联合组总有效率为88.00%,明显高于常规组的70.00%(P<0.05);两组各项药物不良反应发生率、总药物不良反应发生率对比均未见统计学差异(P>0.05);联合组癫痫和总预后不良发生率分别为4.00%和4.00%,明显低于常规组的14.00%和16.00%(P<0.05)。 结论: 对新生儿HIE采用盐酸纳美芬联合mNGF可显著改善脑电活动,获得理想疗效,安全可靠,且还可有效减少不良预后。
Objective: To explore the effect of Nalmefene hydrochloride combined with mouse nerve growth factor (mNGF) in newborns with hypoxic ischemic encephalopathy (HIE), and to analyze on its influence on background electroencephalogram activity and prognosis. Methods: 104 cases of neonatal HIE were selected as subjects and divided into routine group and combined group by simple randomization method. The routine group was given basic support and mNGF therapy. The combined group was given basic support + mNGF + Nalmefene hydrochloride. Background electroencephalogram activity changes before and after treatment, clinical effect, drug adverse reactions and sequel were compared. Results: There was no significant difference in baseline data between the two groups (P> 0.05). After treatment, the incidences of resting, burst-suppression, low voltage, diffuse americium wave and single-rhythm discharges in the two groups decreased significantly (P< 0.05). After treatment, the incidences of abnormal electroencephalogram activity in the combined group were significantly lower than those in the routine group (P< 0.05). The total effective rate was 88.00% in the combined group, which was significantly higher than that of 70.00% in the routine group (P< 0.05). There was no significant difference in the incidence of every drug adverse reaction and total drug adverse reactions between the two groups (P> 0.05). The incidences of epilepsy and total poor prognosis in the combined group were 4.00% and 4.00%, respectively, which were significantly lower than those of 14.00% and 16.00% in the routine group (P< 0.05). Conclusion: Nalmefene hydrochloride combined with mNGF for neonatal HIE can significantly improve electroencephalogram activity, achieve ideal effect, safety and reliability, and effectively reduce adverse prognosis.
作者
丁丽丽
王军
DING Lili;WANG Jun(Xuzhou Children's Hospital,Jiangsu Xuzhou 221000,China)
出处
《河北医学》
CAS
2020年第1期97-101,共5页
Hebei Medicine
关键词
新生儿
缺血缺氧性脑病
盐酸纳美芬
鼠神经生长因子
脑电图背景活动
Newborns
Hypoxic ischemic encephalopathy
Background electroencephalogram activity
Nalmefene hydrochloride
Mouse nerve growth factor
