摘要
目的:探讨Ⅲ型高脂蛋白血症合并肾损害患者的临床病理特征。方法:回顾分析3例(2例女性,1例男性)Ⅲ型高脂蛋白血症合并肾损害患者的临床、实验室指标及病理特点。结果:3例患者均表现为蛋白尿,无镜下血尿,血脂及载脂蛋白E(ApoE)升高,肾小球内可见CD68染色阳性的泡沫细胞,电镜下泡沫细胞胞质内见脂性空泡和(或)致密层状的嗜锇性小体分布。结论:Ⅲ型高脂蛋白血症可引起肾脏损害,病理表现为肾小球系膜区和袢内泡沫细胞聚集。
Objective:To explore clinicopathological features of 3 patients with type Ⅲ hyperlipoproteinemia and renal diseases. Methodology:Three patients with type Ⅲ hyperlipoproteinemia and renal biopsy-proven kidney diseases were retrospectively evaluated. The clinical manifestation and pathological features were analyzed. Results:All three patients(2 females and 1 male) had proteinuria,significantly elevated blood lipids and apolipoprotein E(ApoE),but without microhematuria.Histopathology revealed presence of CD68 positive foam cells in the glomerulus.Electron microscopy showed lipid vacuoles or osmiophilic lamellar bodies in the cytoplasm of foam cells. Conclusion:Renal diseases associated with type Ⅲ hyperlipoproteinemia was characterized by proteinuria,hyperlipidemia,and increased glomerular volume with foam cells infiltration.
作者
钟永忠
朱莹
曾彩虹
ZHONG Yongzhong;ZHU Ying;ZENG Caihong(National Clinical Research Center of Kidney Diseases,Jinling Hospital,Nanjing University School of Medicine,Nanjing 210016,China;Departmgent of Nephrology,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou 310007,China)
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2019年第5期418-422,434,共6页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
国家重点研发计划项目(2016YFC0901202)
