摘要
目的探讨孕晚期发生胎膜早破的危险因素及其与胎膜早破的相关性。方法回顾性分析2017年1月至2018年12月医院收治的350例孕晚期孕妇的临床资料,根据孕妇有无发生胎膜早破分为观察组和对照组。对比两组可能导致胎膜早破相关因素的差异,并采用多因素Logistic回归分析法明确影响胎膜早破的相关因素,重点探讨GBS、支原体、衣原体感染与胎膜早破的关系。结果350例孕妇胎膜早破发生率为14.86%(52/350)0观察组与对照组年龄、主动或被动吸烟、产次、人工流产史、妊娠期高血压、妊娠期糖尿病、胎位横位/臀位和子宫肌瘤患者构成比差异均无统计学意义(均P>0.05)o观察组多胎妊娠、产检V5次、巨大儿、羊水过多、头盆不称、GES感染、解腺支原体感染和沙眼衣原体感染患者构成比均高于对照组,差异有统计学意义(均P<0.05)o经Logistic回归分析均是导致胎膜早破的危险因素(均PV0.05)。结论导致胎膜早破的危险因素较多,其中孕晚期生殖道GES、支原体和衣原体感染与胎膜早破关系紧密,临床应采取针对性防治措施,以降低胎膜早破发生风险,改善妊娠结局。
Objective To investigate the relationship between infections of birth canal Group B Hemolytic streptococcus(GBS),Mycoplasma and Chlamydia and premature rupture of fetal membranes(PRFM),and analyze its risk factors. Methods The clinical data of 350 pregnant women in the third trimester of pregnancy admitted to the hospital from January 2017 to December 2018 were retrospectively analyzed.According to the follow-up of PRFM,they were divided into the observation group or the control group.The differences between the two groups in the factors that may lead to PRFM were observed.Multivariate Logistic regression analysis was used to identify the related factors affecting PRFM,focusing on the relationship between infections of GBS,Mycoplasma and Chlamydia and PRFM. Results The incidence of PRFM in the 350 pregnant and lying-in women was 14.86%(52/350).There were no significant differences in the proportion of age,active or passive smoking,delivery times,history of induced abortion,pregnancy induced hypertension,gestational diabetes mellitus,transverse/gluteal position of fetus and uterine leiomyoma between the two groups(Ps>0.05).The proportions of multiple pregnancies,less than 5 times of maternity examination,macrosomia,polyhydramnios,cephalopelvic disproportion,GBS infection,Ureaplasma urealyticum infection and Chlamydia trachomatis infection in the observation group were higher than those in the control group(all P<0.05).Logistic regression analysis showed that all of them were risk factors for PRFM(OR=7.622,15.090,2.570,4.482,3.111,11.577,5.760,2.298,all P<0.05). Conclusion There are many risk factors for PRFM,and birth canal genital tract infections of GBS,Mycoplasma and Chlamydia are closely related to PRFM.Targeted prevention and treatment measures should be taken in clinical practice to reduce the risk of PRFM and improve pregnancy outcomes.
作者
于曼
杨亚君
YU Man;YANG Yajun(Obstetrics and Gynecology,Chongqing Maternal and Child Health Hospital,Chongqing 400010,China)
出处
《中国微生态学杂志》
CAS
CSCD
2019年第12期1440-1444,共5页
Chinese Journal of Microecology
关键词
孕晚期
E族溶血性链球菌
支原体
衣原体
胎膜早破
Late pregnancy
Group B hemolytic streptococcus
Mycoplasma
Chlamydia
Premature rupture of fetal membranes
