摘要
目的探讨1例肺恶性肿瘤患者在口服安罗替尼期间出现低钠血症的病因,以及实施对症治疗的措施。方法通过对1例右肺恶性肿瘤患者低钠血症的病历资料进行分析,归纳患者可能发生低钠血症的原因。结果结合患者的病情变化、化疗方案、肾功能和血/尿渗透压的检测,分析认为导致患者发生低钠血症的原因为抗利尿激素分泌不当综合征。结论临床药师在药学查房时遇到低钠血症患者常规补钠治疗无效时,应考虑抗利尿激素分泌不当综合征。根据检验指标进行全面细致的筛查,及时反馈医生,以免出现漏诊和贻误病情。
Objective To investigate the causes of hyponatremia during oral administration of anlotinib in a patient with pulmonary malignancy,and to make symptomatic treatment.Methods The possible causes of hyponatremia were summarized by reading and analyzing the medical records of a patient with right lung malignant tumor.Results According to the changes of the patient’s condition,chemotherapy regimen,renal function and blood/urine osmotic pressure,it was concluded that the cause of hyponatremia was the syndrome of inappropriate antidiuretic hormone secretion (SIADH).Conclusion SIADH should be considered when clinical pharmacists encounter the inefficacy of sodium supplementation in patients with hyponatremia during pharmaceutical rounds.It is necessary to make comprehensive and detailed screening according to the test indicators and report it to doctors in time,so as to avoid from missed diagnosis and delayed illness.
作者
杜旭
熊成欢
龙光英
全香花
DU Xu;XIONG Chenghuan;LONG Guangying;QUAN Xianghua(Department of Pharmacy,the Second Affiliated Hospital of Guizhou Traditional Chinese Medicine University,Guiyang,Guizhou,550003,China;Department of Pharmacy,Guizhou Provincial People's Hospital,Guiyang,Guizhou,550002,China;Department of Pharmacy,Affiliated Hospital of Qingdao University,Qingdao,Shandong,266003,China)
出处
《肿瘤药学》
CAS
2019年第6期939-942,951,共5页
Anti-Tumor Pharmacy
