摘要
目的探讨氟哌噻吨美利曲辛片联合帕罗西汀治疗卵巢癌化疗后焦虑抑郁的疗效及对患者5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)水平、细胞免疫功能与生存质量的影响。方法选取我院收治的卵巢癌化疗患者110例为研究对象,随机分为对照组和观察组,各55例。在常规治疗的基础上,对照组给予帕罗西汀治疗,观察组给予氟哌噻吨美利曲辛片联合帕罗西汀治疗。采用焦虑自评量表(SAS)和抑郁自评量表(SDS)评价患者焦虑抑郁的临床疗效。采用世界卫生组织生存质量测定量表简表(WHO QOL-BREF)评价生存质量。治疗8周后,比较两组患者的SAS和SDS评分、5-HT和BDNF水平、细胞免疫功能指标及生存质量。结果治疗8周后,观察组SAS和SDS评分显著低于对照组(P<0.05),5-HT和BDNF水平明显高于对照组(P<0.05)。治疗后,观察组CD4^+水平及CD4^+/CD8^+均显著高于对照组(P<0.05);两组间CD8^+水平无明显差异(P>0.05)。治疗后,观察组生理、心理、社会维度评分及生存质量总评分均明显高于对照组(P<0.05),而两组间环境维度评分无明显差异(P>0.05)。结论氟哌噻吨美利曲辛片联合帕罗西汀治疗卵巢癌化疗患者焦虑抑郁的效果良好,可提高其5-HT、BDNF水平,改善其细胞免疫功能和生存质量,值得临床进一步研究。
Objective To investigate the curative efficacy of flupentixol and melitracen tablets in combination with paroxetine on anxiety and depression in patients with ovarian cancer after chemotherapy,and its influences on levels of 5-hydroxy tryptamin (5-HT),brain-derived neurotrophic factor (BDNF),cellular immune function and quality of life.Methods A total of 110 patients with ovarian cancer after chemotherapy were collected as observational objects.They were randomly divided into control group and observation group,with 55 cases in each group.Besides conventional treatments,the control group was treated with paroxetine,while the observation group was treated with flupentixol and melitracen tablets in combination with paroxetine.Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were employed to assess the curative efficacy of anxiety and depression.And brief scale of WHO quality of life was employed to assess the quality of life.After eight weeks,scores of SAS and SDS,levels of 5-HT and BDNF,indices of cellular immune function and quality of life were compared between the two groups.Results After eight weeks,in comparison with the control group,the observation group had lower scores of SAS and SDS,and higher levels of 5-HT and BDNF with all statistical differences (P<0.05).Cellular immune function showed that the CD4^+ level and CD4^+/CD8^+ in the observation group were statistically higher than those in the control group after treatment (P<0.05),while the level of CD8^+ showed no statistical differences between the two groups after treatment (P>0.05).As to life of quality,the scores of physiology,psychology and society,and the total scores in the observation group were higher than those in the control group after treatment,all with statistical differences (P<0.05).But scores of circumstance had no statistical differences between the two groups after treatment (P>0.05).Conclusion The flupentixol and melitracen tablets in combination with paroxetin had curative effects on anxiety and depression in patients with ovarian cancer after chemotherapy.And it could increase the levels of 5-HT and BDNF,and improve cellular immune function and quality of life.
作者
王景
李小梅
洪苑
徐卫霞
WANG Jing;LI Xiaomei;HONG Yuan;XU Weixia(Sichuan Nursing Vocational College,Chengdu,Sichuan,610100,China;Zhaoqing Medical College,Zhaoqing,Guangdong,526020,China;Zhaoqing First People's Hospital,Zhaoqing,Guangdong,526000,China;Ya'an People's Hospital,Ya'an,Sichuan,625000,China)
出处
《肿瘤药学》
CAS
2019年第6期929-932,938,共5页
Anti-Tumor Pharmacy
关键词
氟哌噻吨美利曲辛片
帕罗西汀
卵巢癌
化疗
焦虑抑郁
5-羟色胺
脑源性神经营养因子
细胞免疫功能
生存质量
Flupentixol and melitracen tablets
Paroxetin
Ovarian cancer
Chemotherapy
Anxiety and depression
5-hydroxy tryptamin
Brain-derived neurotrophic factor
Cellular immune function
Quality of life
