摘要
目的:探讨噻托溴铵粉联合沙丁胺醇对慢阻肺急性加重期患者肺功能及血清TNF-α、IL-6水平的影响。方法:选择笔者所在医院呼吸内科2017年1月-2019年3月收治的120例慢阻肺急性加重期患者,按照随机数字表法分为两组,每组60例。对照组给予沙丁胺醇,观察组给予沙丁胺醇+噻托溴铵粉,比较两组临床疗效、症状改善情况、肺通气功能指标、动脉血气分析指标、血清炎症因子指标。结果:观察组临床总有效率为96.67%,高于对照组的81.67%,差异有统计学意义(P<0.05)。观察组咳嗽、咳痰、气促等症状缓解时间均短于对照组,差异均有统计学意义(P<0.05)。两组治疗后FEV1、FEV1/FVC均高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组治疗后PaO2、PaCO2均优于治疗前,且观察组PaO2高于对照组高,PaCO2低于对照组,差异均有统计学意义(P<0.05)。两组治疗后CRP、TNF-α、IL-6水平均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。结论:沙丁胺醇与噻托溴铵粉联合应用可提高慢阻肺急性加重期患者的疗效,改善其肺功能,减轻其气道炎症反应。
Objective:To investigate the effects of Tiotropium Bromide combined with Salbutamol on lung function and serum TNF-αand IL-6 levels in patients with acute exacerbation of chronic obstructive pulmonary disease.Method:One hundred and twenty patients with acute exacerbation of chronic obstructive pulmonary disease admitted to our hospital from January 2017 to March 2019 were randomly divided into two groups,with 60 patients in each group,and the control group was given Salbutamol,the observation group was given Salbutamol+Tiotropium Bromide.The clinical efficacy,symptom improvement,pulmonary ventilation function index,arterial blood gas analysis index and serum inflammatory factor index were compared between the two groups.Result:The total effective rate of the observation group was 96.67%,which was higher than 81.67%of the control group,the difference was statistically significant(P<0.05).The time to relieve symptoms such as cough,phlegm and shortness of breath of the observation group were shorter than the control group,the differences were statistically significant(P<0.05).The FEV1 and FEV1/FVC of the two groups were higher than those before treatment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).The PaO2 and PaCO2 after treatment were better than those before treatment,and the PaO2 of the observation group was higher than that of the control group,the PaCO2 was lower than that of the control group,the differences were statistically significant(P<0.05).The levels of CRP,TNF-αand IL-6 in the two groups were lower than those before treatment,while the observation group was lower than the control group,the differences were statistically significant(P<0.05).Conclusion:The combination of Salbutamol and Tiotropium Bromide powder can improve the curative effect of patients with acute exacerbation of chronic obstructive pulmonary disease,improve their lung function and reduce their airway inflammation.
作者
严明
钟翠敏
王伟
陈雨亮
YAN Ming;ZHONG Cuimin;WANG Wei;CHEN Yuliang(Ezhou City Chinese Medicine Hospital,Ezhou 436001,China)
出处
《中外医学研究》
2019年第34期134-136,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
慢性阻塞性肺疾病
噻托溴铵
沙丁胺醇
肺功能
Chronic obstructive pulmonary
Tiotropium Bromide
Salbutamol
Lung function
