摘要
目的:回顾性分析病程超过3年的早发型重症肌无力(EOMG)与晚发型重症肌无力(LOMG)的临床特点和预后.方法:记录重症肌无力(MG)患者的一般资料(临床特征、胸腺异常、合并症)、辅助检查及预后情况,综合分析EOMG与LOMG临床差异,并随访治疗效果.结果:LOMG患者中男45例(67.16%),多于EOMG男患者;LOMG患者中女22例(32.84%),少于EOMG女患者,差异有统计学意义(P=0.023).EOMG患者中OMG多于LOMG,GMG少于LOMG,差异有统计学意义(P=0.002).EOMG患者中重复性神经刺激(RNS)阳性99例(86.09%),多于LOMG的28例(70.00%),差异有统计学意义(P=0.023).EOMG患者伴胸腺增生为21.51%,高于LOMG患者的7.46%,差异有统计学意义(P=0.010).EOMG患者伴自身免疫性疾病为18.81%,高于LOMG患者的7.46%,差异有统计学意义(P=0.029).OMG首发年龄高峰期为40~44岁(25例),LOMG首发年龄高峰期为55~59岁(21例).EOMG患者中有效率显著高于LOMG,差异有统计学意义(P=0.047).结论:性别、首发MG类型、有无胸腺增生及自身免疫性疾病对EOMG、LOMG患者临床特征的识别具有潜在意义,对指导MG的诊断及治疗有重要作用.
Objective:To retrospectively analyze the clinical features and prognosis of early onset myasthenia gravis(EOMG)and late onset myasthenia gravis(LOMG),whose disease duration was more than 3 years.Method:The general informations(clinical features,thymus abnormalities,comorbidities),auxiliary examinations and prognosis of patients with myasthenia gravis(MG)were recorded.The clinical differences between EOMG and LOMG were comprehensively analyzed,and therapeutic effects were followed up.Result:There were 45 male patients(67.16%)in LOMG,more than male patients in EOMG,and there were 22 female patients(32.84%)in LOMG,less than female patients in EOMG,and the difference was statistically significant(P=0.023).There were more OMG patients in EOMG patients than LOMG,and less GMG patients than LOMG,and the difference was statistically significant(P=0.002).In EOMG patients,99 patients(86.09%)were positive for repetitive nerve stimulation(RNS),which was more than 28 patients(70.00%)of LOMG,and the difference was statistically significant(P=0.023).EOMG patients with thymic hyperplasia was 21.51%,which was higher than 7.46%of the LOMG patients,and the difference was statistically significant(P=0.010).EOMG patients with autoimmune diseases was 18.81%,which was higher than 7.46%of the LOMG patients,and the difference was statistically significant(P=0.029).The peak age of OMG’s debut is 40 to 44 years old(25 cases),and the peak age of GMG’s debut is 55 to 59 years old(21 cases).The effective rate of EOMG patients was significantly higher than that of LOMG patients,and the difference was statistically significant(P=0.047).Conclusion:Sex,type of MG onset,presence or absence of thymic hyperplasia and autoimmune diseases have potential significance in the identification of clinical features of EOMG and LOMG.It plays an important role in guiding the diagnosis and treatment of myasthenia gravis.
作者
宁金环
刘肇绩
沈丛萍
刘赞华
陈星宇
NING Jinhuan;LIU Zhaoji;SHEN Congping;LIU Zanhua;CHEN Xingyu(Nanjing Gaochun People’s Hospital,Nanjing 211300,China;不详)
出处
《中外医学研究》
2019年第34期3-6,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
重症肌无力
早发型
晚发型
疗效
Myasthenia gravis
Early onset
Late onset
Curative effect
