摘要
目的:研究奥曲肽联合乌司他丁治疗急性胰腺炎的临床效果及对炎症因子水平的影响。方法:取2017年11月-2018年10月笔者所在医院消化科急性胰腺炎患者70例作为研究对象,随机分为对照组与研究组,在综合治疗的基础上,对照组患者采用奥曲肽进行治疗,研究组患者采用奥曲肽联合乌司他丁用药治疗。连续用药10 d,观察两组的治疗效果炎症因子指标的变化情况。结果:与对照组比较,研究组腹痛、恶心呕吐、腹胀、发热等症状表现持续时间及住院天数明显短于对照组,差异有统计学意义(P<0.05);在治疗后,两组C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子(TNF)、白细胞介素-1β、6、8(IL-1β、IL-6、IL-8)都明显低于治疗前,差异有统计学意义(P<0.05),且研究组的各项炎性因子指标水平均明显低于对照组,差异有统计学意义(P<0.05)。结论:奥曲肽联合乌司他丁能够更快速缓解患者入院时的表现症状,能够有效地抑制并减少患者体内CRP、TNF、IL-1β、IL-6、IL-8等炎性因子的水平,在急性胰腺炎的临床治疗中可以显著提高临床效果,值得在临床工作中推广使用。
Objective:To study the clinical effect of Octreotide combined with Ulinastatin on acute pancreatitis and its effect on inflammatory factor levels.Method:From November 2017 to October 2018,70 patients with acute pancreatitis in our hospital were randomly divided into the control group and the study group.On the basis of comprehensive treatment,the control group was treated with Octreotide.The patient in the study group was treated with Octreotide plus Ulinastatin.After continuous administration for 10 days,the therapeutic effects of the two groups of patients and the changes of inflammatory factor indicators were observed.Result:Compared with the control group,the duration of symptoms and hospitalization days of patients with abdominal pain,nausea and vomiting,abdominal distension,and fever were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the C-reactive protein(CRP),tumor necrosis factor(TNF),interleukin-1β,6,8(IL-1β,IL-6,IL-8)were significantly lower than before treatment,the data were statistically significant(P<0.05),and the inflammatory factor index of the study group were significantly lower than those of the control group.The differences were statistically significant(P<0.05).Conclusion:Octreotide combined with Ulinastatin can more quickly relieve the symptoms of patients when they are admitted to hospital,and can effectively inhibit and reduce the levels of CRP,TNF,IL-1β,IL-6,IL-8 and other inflammatory factors in patients.In the clinical treatment of acute pancreatitis,the clinical effect can be significantly improved,and it is worthy of popularization in clinical work.
作者
李俊萍
LI Junping(Xiamen Third Hospital,Xiamen 361100,China)
出处
《中外医学研究》
2019年第35期170-172,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
奥曲肽
乌司他丁
急性胰腺炎
C反应蛋白
Octreotide
Ulinastatin
Acute pancreatitis
C-reactive protein
