摘要
目的:探讨血清胆红素、脂联素水平及血液流变学指标与早期糖尿病肾病的关系。方法:选择笔者所在医院2018年1月-2019年3月收治的86例2型糖尿病(T2MD)患者,依据24 h尿白蛋白定量将其分为A组(肾病组32例)与B组(非肾病组54例),同期收集42例体检正常健康人列为C组(健康组),对比分析三组血清胆红素、脂联素水平及血液流变学指标差异。结果:(1)血清直接胆红素、间接胆红素及总胆红素水平方面,A组B组>C组,差异有统计学意义(P<0.05);(2)A组和B组红细胞聚集指数、全血黏度(低切)、全血黏度(高切)值均高于C组,差异有统计学意义(P<0.05);A组血细胞比容及纤维蛋白原水平高于C组,差异有统计学意义(P<0.05);(3)血清直接胆红素、间接胆红素及总胆红素与24 h尿白蛋白定量均呈负相关(P<0.05),血清脂联素、红细胞聚集指数、纤维蛋白原与24 h尿白蛋白定量均呈正相关(P<0.05)。结论:血清胆红素、脂联素水平及血液流变学指标与早期糖尿病肾病具有相关性,血清胆红素是糖尿病肾病的保护因素,脂联素及血液高凝状态是糖尿病肾病的危险因素,糖尿病早期适当改善血液高凝状态有利于预防糖尿病肾病。
Objective:To investigate the relationship between serum bilirubin,and adiponectin levels,hemorheological indexes and early diabetic nephropathy.Method:Eighty-six patients with type 2 diabetes mellitus(T2MD)who were admitted to the hospital from January 2018 to March 2019 were enrolled in the study.They were divided into group A(nephropathy group,32 cases)and group B(no nephropathy group,54 cases)according to 24 h urinary albumin quantification.A total of 42 healthy subjects were selected as group C(healthy group)at the same time.Serum bilirubin and adiponectin levels,hemorheological indexes were compared among the three groups.Result:(1)Serum direct bilirubin,indirect bilirubin and total bilirubin levels were the lowest in group A,followed by group B and group C(P<0.05).The adiponectin level was the highest in group A,followed by group B and group C(P<0.05).(2)The erythrocyte aggregation index,whole blood viscosity(low shear)and whole blood viscosity(high shear)of group A and group B were higher than those of group C(P<0.05).The hematokrit and fibrinogen levels in group A were higher than those in group C(P<0.05).(3)Serum direct bilirubin,indirect bilirubin and total bilirubin were negatively correlated with 24 h urinary albumin quantification(P<0.05).Serum adiponectin,erythrocyte aggregation index and fibrinogen were positively correlated with 24 h urinary albumin quantification(P<0.05).Conclusion:Serum bilirubin and adiponectin levels and hemorheologicalindexes are associated with early diabetic nephropathy.Serum bilirubin is a protective factor for diabetic nephropathy.Adiponectin and hypercoagulable state are risk factors for diabetic nephropathy.Properly improving the hypercoagulable state in early stage of diabetes is beneficial to prevent diabetic nephropathy.
作者
李伦
LI Lun(Xiaogan First People’s Hospital,Xiaogan 432000,China)
出处
《中外医学研究》
2019年第35期63-65,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
